TY - JOUR
T1 - Influence of Intrinsic and Lifestyle Factors on the Development of IgE Sensitization
AU - Stemeseder, T.
AU - Klinglmayr, E.
AU - Moser, S.
AU - Lang, R.
AU - Himly, M.
AU - Oostingh, G.J.
AU - Zumbach, J.
AU - Bathke, A.C.
AU - Hawranek, T.
AU - Gadermaier, G.
N1 - Cited By :19
Export Date: 14 December 2023
CODEN: IAAIE
Correspondence Address: Gadermaier, G.; Department of Molecular Biology, Hellbrunnerstrasse 34, Austria; email: [email protected]
Chemicals/CAS: immunoglobulin E, 37341-29-0; profilin, 131383-86-3; Allergens; Immunoglobulin E
Tradenames: ImmunoCAP ISAC
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PY - 2017
Y1 - 2017
N2 - Background: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. Methods: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®. Allergic sensitization, IgE levels to single allergens, and ISAC score sums were correlated with results obtained from a questionnaire. Results: In this adolescent cohort, male participants showed a higher sensitization frequency (56.8%) compared to females (50.9%) and significantly increased IgE levels to profilins. Underweight subjects demonstrated a stronger IgE sensitization. Family size inversely correlated with IgE levels to PR-10 allergens, and predominately paternal allergies were a predictive factor for IgE sensitization in the children. Vaccination, breastfeeding, and delivery mode showed no influence, while a highly protective effect was observed for growing up on a farm. Of all of the investigated lifestyle factors, only smoking significantly influenced the risk for IgE development. Participants with moderate frequencies of colds showed increased sensitization levels. Conclusion: A hereditary predisposition and lifestyle factors such as a farming environment, smoking, family size, body weight, or frequency of colds significantly influenced the development of allergen-specific IgE in this cohort of adolescents. © 2017 S. Karger AG, Basel. All rights reserved.
AB - Background: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. Methods: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®. Allergic sensitization, IgE levels to single allergens, and ISAC score sums were correlated with results obtained from a questionnaire. Results: In this adolescent cohort, male participants showed a higher sensitization frequency (56.8%) compared to females (50.9%) and significantly increased IgE levels to profilins. Underweight subjects demonstrated a stronger IgE sensitization. Family size inversely correlated with IgE levels to PR-10 allergens, and predominately paternal allergies were a predictive factor for IgE sensitization in the children. Vaccination, breastfeeding, and delivery mode showed no influence, while a highly protective effect was observed for growing up on a farm. Of all of the investigated lifestyle factors, only smoking significantly influenced the risk for IgE development. Participants with moderate frequencies of colds showed increased sensitization levels. Conclusion: A hereditary predisposition and lifestyle factors such as a farming environment, smoking, family size, body weight, or frequency of colds significantly influenced the development of allergen-specific IgE in this cohort of adolescents. © 2017 S. Karger AG, Basel. All rights reserved.
KW - Allergen sensitization
KW - Antigens/allergens
KW - Childhood
KW - Environmental factors
KW - Epidemiology
KW - Farm environment
KW - IgE antibodies
KW - Microarray
KW - Molecular diagnostics
KW - allergen
KW - immunoglobulin E
KW - intrinsic factor
KW - profilin
KW - adolescent
KW - adult
KW - allergy rapid test
KW - Article
KW - Austrian
KW - breast feeding
KW - child
KW - cold
KW - controlled study
KW - family size
KW - female
KW - human
KW - immunoglobulin blood level
KW - lifestyle
KW - major clinical study
KW - male
KW - priority journal
KW - sensitization
KW - smoking
KW - vaccination
KW - agricultural land
KW - Austria
KW - blood
KW - hypersensitivity
KW - immunology
KW - young adult
KW - Adolescent
KW - Adult
KW - Allergens
KW - Child
KW - Farms
KW - Humans
KW - Hypersensitivity
KW - Immunoglobulin E
KW - Life Style
KW - Smoking
KW - Young Adult
U2 - 10.1159/000475499
DO - 10.1159/000475499
M3 - Article
SN - 1018-2438
VL - 173
SP - 99
EP - 104
JO - Int. Arch. Allergy Immunol.
JF - Int. Arch. Allergy Immunol.
IS - 2
ER -
