TY - JOUR
T1 - Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling
AU - Stemeseder, T.
AU - Klinglmayr, E.
AU - Moser, S.
AU - Lueftenegger, L.
AU - Lang, R.
AU - Himly, M.
AU - Oostingh, G.J.
AU - Zumbach, J.
AU - Bathke, A.C.
AU - Hawranek, T.
AU - Gadermaier, G.
N1 - Cited By :38
Export Date: 14 December 2023
CODEN: LLRGD
Correspondence Address: Gadermaier, G.; Department of Molecular Biology, Austria; email: [email protected]
Chemicals/CAS: immunoglobulin E, 37341-29-0; Allergens; Immunoglobulin E
Tradenames: ImmunoCAP ISAC
Funding text 1: C. Wageneder-Schmid and the Biomedical Sciences team of the Salzburg University of Applied Sciences (K. Schwenoha, L. Helminger, J. Gmachl-Baumgartner, R. Wiltsche, U. Fötschl) are acknowledged for their support regarding study design and carrying out the blood sampling, respectively. Further we thank the teachers E. Oberkofler (HBLA Ursprung), M. Hauer (BG Tamsweg), S. Fischinger (NMS Bürmoos), K. Schaffer (PdC BORG Radstadt), B. Wanzenböck (Musisches Gymnasium Salzburg), J. Pöttler (BG Seekirchen), R. Pilotto-Kofler and P. Paraschin-Wolfsberger (PG St. Rupert), M. Anderluch (BHAK/BHAS I Salzburg), G. Mussill and L. Mackner-Rath (BORG Nonntal), and the pupils of the participating schools for supporting the project.
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PY - 2017
Y1 - 2017
N2 - Background: Allergen-specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis.
Methods: Serum samples of 501 nonselected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC® for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies.
Results: In the population aged 12–21 years, 53.5% showed IgE reactivity to at least one allergen tested. The highest prevalence was found for Phl p 1 from grass pollen (26.5%), group 2 mite allergens (18.2%), Bet v 1 from birch pollen (16.3%) and Fel d 1 from cat (14.4%). The majority of participants showed a complex sensitization profile and reacted on average to 9 allergens. Pollen sensitization was highly prevalent (41.7%) and mainly driven by group I grass and PR-10 allergens of the Betulaceae family, while Pla l 1 represented the most relevant weed. Diagnosed and self-reported allergies were noted in 21.9% and 45.5% of participants, respectively, and correlated well with in vitro results. Among atopic individuals, 71.4% reported to suffer from at least one allergy; concordance was found for grass and cat sensitization, while venom- and weed pollen-positive individuals were frequently asymptomatic.
Conclusions: More than half of the tested adolescent population had already established an atopic status presenting a complex IgE reactivity profile dominated by pollen sensitization. Detailed molecule-based analysis allows determining relevant biomarkers and monitoring of the atopic status in populations. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
AB - Background: Allergen-specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis.
Methods: Serum samples of 501 nonselected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC® for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies.
Results: In the population aged 12–21 years, 53.5% showed IgE reactivity to at least one allergen tested. The highest prevalence was found for Phl p 1 from grass pollen (26.5%), group 2 mite allergens (18.2%), Bet v 1 from birch pollen (16.3%) and Fel d 1 from cat (14.4%). The majority of participants showed a complex sensitization profile and reacted on average to 9 allergens. Pollen sensitization was highly prevalent (41.7%) and mainly driven by group I grass and PR-10 allergens of the Betulaceae family, while Pla l 1 represented the most relevant weed. Diagnosed and self-reported allergies were noted in 21.9% and 45.5% of participants, respectively, and correlated well with in vitro results. Among atopic individuals, 71.4% reported to suffer from at least one allergy; concordance was found for grass and cat sensitization, while venom- and weed pollen-positive individuals were frequently asymptomatic.
Conclusions: More than half of the tested adolescent population had already established an atopic status presenting a complex IgE reactivity profile dominated by pollen sensitization. Detailed molecule-based analysis allows determining relevant biomarkers and monitoring of the atopic status in populations. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
KW - allergen microarray
KW - epidemiology
KW - IgE
KW - molecule-based diagnosis
KW - sensitization
KW - allergen
KW - biological marker
KW - carbohydrate
KW - food allergen
KW - house dust allergen
KW - immunoglobulin E
KW - insect venom
KW - latex
KW - pollen antigen
KW - adolescent
KW - adult
KW - allergy
KW - allergy rapid test
KW - Article
KW - atopy
KW - Austrian
KW - Betulaceae
KW - birch
KW - cat
KW - cereal
KW - child
KW - cockroach
KW - cross-sectional study
KW - egg
KW - female
KW - fish
KW - fruit
KW - grass pollen
KW - human
KW - in vitro study
KW - legume
KW - major clinical study
KW - male
KW - mould
KW - nut
KW - patient monitoring
KW - prevalence
KW - priority journal
KW - self report
KW - shrimp
KW - tree
KW - vegetable
KW - weed
KW - Austria
KW - hypersensitivity
KW - immediate type hypersensitivity
KW - immunology
KW - young adult
KW - Adolescent
KW - Adult
KW - Allergens
KW - Child
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Hypersensitivity
KW - Hypersensitivity, Immediate
KW - Immunoglobulin E
KW - Male
KW - Prevalence
KW - Young Adult
U2 - 10.1111/all.13071
DO - 10.1111/all.13071
M3 - Article
SN - 0105-4538
VL - 72
SP - 754
EP - 763
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 5
ER -
SDG 3 Good Health and Well-being