TY - JOUR
T1 - Compounds extracted from larch, birch bark, douglas fir, and alder woods with four different solvents: Effects on five skin-related microbes
AU - Schuster, A.
AU - Ortmayr, N.
AU - Oostingh, G.J.
AU - Stelzhammer, B.
N1 - Cited By :4
Export Date: 14 December 2023
Correspondence Address: Schuster, A.; Salzburg University of Applied SciencesAustria; email: [email protected]
Funding details: 7081_017
Funding text 1: The authors are grateful for the financial support of the institutional Health Science Funding (Project Number: 7081_017). In addition, the authors thank the Department of Forest Products Technology and Timber Construction at the Salzburg University of Applied Sciences for providing the wood samples. The Department of Microbiology at the Salzburg University Hospital is acknowledged for providing some of the bacterial strains.
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PY - 2020/3/25
Y1 - 2020/3/25
N2 - Wood is an important natural resource, and the extracts of specific wood species might have growth-inhibiting effects on certain microbes. This property can be used in the pharmaceutical industry to develop phytochemical-based medicine to treat skin infections. Thus far, methanol, intrinsically toxic, has been the main solvent used for extraction of soluble wood compounds. In this study, the focus was placed on biocompatible solvents, including dimethyl sulfoxide, distilled water, and glycerin, in addition to methanol used to extract compounds from larch, birch bark, Douglas fir, and alder wood sawdust. Microbial growth was tested on four different bacterial strains and one type of fungi representing species that can affect the skin. The results revealed intrinsic toxicity of biocompatible solvents at low concentrations as well as an additive or synergistic effect of wood extracts. In particular, larch and birch extracts strongly decreased microbial growth. In addition, interference of the extract color on the measurements was observed, which must be taken into account to ensure correct analysis of the data. In conclusion, biocompatible solvents in conjunction with larch and birch extracts exhibited antimicrobial effects. The importance of solvent toxicity and background staining were highlighted to determine potential antimicrobial effects.
AB - Wood is an important natural resource, and the extracts of specific wood species might have growth-inhibiting effects on certain microbes. This property can be used in the pharmaceutical industry to develop phytochemical-based medicine to treat skin infections. Thus far, methanol, intrinsically toxic, has been the main solvent used for extraction of soluble wood compounds. In this study, the focus was placed on biocompatible solvents, including dimethyl sulfoxide, distilled water, and glycerin, in addition to methanol used to extract compounds from larch, birch bark, Douglas fir, and alder wood sawdust. Microbial growth was tested on four different bacterial strains and one type of fungi representing species that can affect the skin. The results revealed intrinsic toxicity of biocompatible solvents at low concentrations as well as an additive or synergistic effect of wood extracts. In particular, larch and birch extracts strongly decreased microbial growth. In addition, interference of the extract color on the measurements was observed, which must be taken into account to ensure correct analysis of the data. In conclusion, biocompatible solvents in conjunction with larch and birch extracts exhibited antimicrobial effects. The importance of solvent toxicity and background staining were highlighted to determine potential antimicrobial effects.
KW - Biocompatible solvents
KW - Extract background staining
KW - Intrinsic solvent toxicity
KW - Microbial growth
KW - Wood extracts
KW - Bacteria
KW - Biocompatibility
KW - Dimethyl sulfoxide
KW - Methanol
KW - Toxicity
KW - Wood
KW - Anti-microbial effects
KW - Bacterial strains
KW - Different solvents
KW - Inhibiting effect
KW - Low concentrations
KW - Pharmaceutical industry
KW - Synergistic effect
KW - Organic solvents
KW - Betula
KW - Dimethyl Sulfoxide
KW - Extractives
KW - Larix
UR - https://www.mendeley.com/catalogue/1f302669-00f2-3b22-ba92-497e6de44e2f/
U2 - 10.15376/biores.15.2.3368-3381
DO - 10.15376/biores.15.2.3368-3381
M3 - Article
SN - 1930-2126
VL - 15
SP - 3368
EP - 3381
JO - BioResour.
JF - BioResour.
IS - 2
ER -