Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications

S. Häsler Gunnarsdottir; L. Sommerauer; T. Schnabel; G.J. Oostingh; A. Schuster

doi:10.3390/antibiotics12010130

Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications

S. Häsler Gunnarsdottir
, L. Sommerauer
, T. Schnabel
, G.J. Oostingh
, A. Schuster^*

^*Corresponding author for this work

Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Vienna
Salzburg Center for Smart Materials
Faculty of Furniture Design and Wood Engineering, Transilvania University of Brasov

Research output: Contribution to journal › Review article › peer-review

Abstract

Plant species have developed effective defense strategies for colonizing diverse habitats and protecting themselves from numerous attacks from a wide range of organisms, including insects, vertebrates, fungi, and bacteria. The bark of trees in particular constitutes a number of components that protect against unwanted intruders. This review focuses on the antioxidative, dermal immunomodulatory, and antimicrobial properties of bark extracts from European common temperate trees in light of various skin pathogens, wound healing, and the maintenance of skin health. The sustainability aspect, achieved by utilizing the bark, which is considered a byproduct in the forest industry, is addressed, as are various extraction methods applied to retrieve extracts from bark.

Original language	English
Pages (from-to)	130
Number of pages	1
Journal	Antibiotics
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/antibiotics12010130
Publication status	Published - 9 Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antimicrobial potential
antioxidative potential
dermatology
European wood bark extracts
extraction technologies
Abies alba extract
Acer pseudoplatanus extract
Alnus glutinosa extract
Betula pendula extract
Castanea sativa extract
Fagus sylvatica extract
Fraxinus excelsior extract
glutathione
immunoglobulin enhancer binding protein
Larix decidua extract
malonaldehyde
Picea abies extract
Pinus brutia extract
Pinus pinaster extract
plant extract
Prunus avium extract
Prunus padus extract
Pseudotsuga menziesii extract
Quercus ilex extract
Quercus robur extract
Quercus rubra extract
reactive oxygen metabolite
Salix alba extract
superoxide dismutase
thiobarbituric acid
thiobarbituric acid reactive substance
transcription factor Nrf2
tumor necrosis factor
unclassified drug
ABTS radical scavenging assay
antibacterial activity
antimicrobial activity
antioxidant activity
bark
DNA damage
DPPH radical scavenging assay
extraction
ferric reducing antioxidant power assay
human
hydrodistillation
immune response
immunomodulation
lipid peroxidation
maceration
MAPK signaling
microwave assisted extraction
NF kB signaling
nonhuman
oxidative stress
Pi3K/Akt signaling
Review
Soxhlet extraction
steam distillation
synergistic effect
wound healing
wound healing assay

Classification according to Österreichische Systematik der Wissenschaftszweige (ÖFOS 2012)

205006 Wood research

Applied Research Level (ARL)

ARL Level 3 - Proof of the functionality of a principle

Research focus/foci

Applied Health Innovation
Sustainable Materials and Technologies

Access to Document

10.3390/antibiotics12010130

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146748544&doi=10.3390%2fantibiotics12010130&partnerID=40&md5=1eb2e95ac900652b445dc9965957d345

Cite this

@article{1f90baea73554df99579311671ffa737,

title = "Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications",

abstract = "Plant species have developed effective defense strategies for colonizing diverse habitats and protecting themselves from numerous attacks from a wide range of organisms, including insects, vertebrates, fungi, and bacteria. The bark of trees in particular constitutes a number of components that protect against unwanted intruders. This review focuses on the antioxidative, dermal immunomodulatory, and antimicrobial properties of bark extracts from European common temperate trees in light of various skin pathogens, wound healing, and the maintenance of skin health. The sustainability aspect, achieved by utilizing the bark, which is considered a byproduct in the forest industry, is addressed, as are various extraction methods applied to retrieve extracts from bark.",

keywords = "antimicrobial potential, antioxidative potential, dermatology, European wood bark extracts, extraction technologies, Abies alba extract, Acer pseudoplatanus extract, Alnus glutinosa extract, Betula pendula extract, Castanea sativa extract, Fagus sylvatica extract, Fraxinus excelsior extract, glutathione, immunoglobulin enhancer binding protein, Larix decidua extract, malonaldehyde, Picea abies extract, Pinus brutia extract, Pinus pinaster extract, plant extract, Prunus avium extract, Prunus padus extract, Pseudotsuga menziesii extract, Quercus ilex extract, Quercus robur extract, Quercus rubra extract, reactive oxygen metabolite, Salix alba extract, superoxide dismutase, thiobarbituric acid, thiobarbituric acid reactive substance, transcription factor Nrf2, tumor necrosis factor, unclassified drug, ABTS radical scavenging assay, antibacterial activity, antimicrobial activity, antioxidant activity, bark, DNA damage, DPPH radical scavenging assay, extraction, ferric reducing antioxidant power assay, human, hydrodistillation, immune response, immunomodulation, lipid peroxidation, maceration, MAPK signaling, microwave assisted extraction, NF kB signaling, nonhuman, oxidative stress, Pi3K/Akt signaling, Review, Soxhlet extraction, steam distillation, synergistic effect, wound healing, wound healing assay",

author = "\{H{\"a}sler Gunnarsdottir\}, S. and L. Sommerauer and T. Schnabel and G.J. Oostingh and A. Schuster",

note = "Cited By :1 Export Date: 14 December 2023 Correspondence Address: Schuster, A.; Biomedical Sciences, Urstein Sued 1, Austria; email: [email protected] Chemicals/CAS: glutathione, 70-18-8; malonaldehyde, 542-78-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; thiobarbituric acid, 504-17-6 Funding text 1: This research was funded by a local research funding of the county of Salzburg, grant number 7081032 and the APC was funded by a local research funding of the county of Salzburg, grant number 7015130. References: Tudor, E.M., Huber, H., Bauprodukte aus Rinde (2022) Bauphysik Kalender 2022, pp. 139-169. , Fouad N.A., (ed), Wiley, Hoboken, NJ, USA; Cincinelli, A., Guerranti, C., Martellini, T., Scodellini, R., Residential wood combustion and its impact on urban air quality in Europe (2019) Curr. Opin. Environ. Sci. Health, 8, pp. 10-14; Ramage, M.H., Burridge, H., Busse-Wicher, M., Fereday, G., Reynolds, T., Shah, D.U., Wu, G., Densley-Tingley, D., The wood from the trees: The use of timber in construction (2017) Renew. Sustain. Energy Rev, 68, pp. 333-359; Gejdo{\v s}, M., Suchomel, J., Potential, Prices and Resources of Raw Wood Assortments for the Pulp and Paper Industry in Central Europe (2016) Key Eng. Mater, 688, pp. 210-217; Gordi{\'c}, D., Babi{\'c}, M., Jeli{\'c}, D., Kon{\'c}alovi{\'c}, D., Vuka{\v s}inovi{\'c}, V., Integrating energy and environmental management in wood furniture industry (2014) Sci. World J, 2014, p. 596958. , 24587734; P{\'a}sztory, Z., Moh{\'a}csin{\'e}, I.R., Gorbacheva, G., B{\"o}rcs{\"o}k, Z., The utilization of tree bark (2016) BioResources, 11, pp. 7859-7888; Lee, E.L., Richards, N., Harrison, J., Barnes, J., Prevalence of Use of Traditional, Complementary and Alternative Medicine by the General Population: A Systematic Review of National Studies Published from 2010 to 2019 (2022) Drug Saf, 45, pp. 713-735; Forrai, J., (2011) History of Different Therapeutics of Venereal Disease Before the Discovery of Penicillin, , InTech Open, London, UK; Zhao, J., Zhao, Y., Chen, W., Li, Y.-M., Bian, X.-W., The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8 (2008) Anticancer Drugs, 19, pp. 713-719. , 18594213; Sarkar, A., Datta, P., Das, A.K., Gomes, A., Anti-rheumatoid and anti-oxidant activity of homeopathic Guaiacum officinale in an animal model (2014) Homeopathy, 103, pp. 133-138; Taib, M., Rezzak, Y., Bouyazza, L., Lyoussi, B., Medicinal Uses, Phytochemistry, and Pharmacological Activities of Quercus Species (2020) Evid.-Based Complement. Altern. Med, 2020, p. 1920683; Fraga-Corral, M., Otero, P., Cassani, L., Echave, J., Garcia-Oliveira, P., Carpena, M., Chamorro, F., Simal-Gandara, J., Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility (2021) Foods, 10; Belcaro, G., Hosoi, M., Feragalli, B., Luzzi, R., Dugall, M., Supplementation with Robuvit{\textregistered} in subjects with burnout associated to high oxidative stress (2018) Minerva Med, 109, pp. 211-217. , 29164838; Ippolito, E., Belcaro, G., Luzzi, R., Hosoi, M., Dugall, M., Rohdewald, P., Feragalli, B., Peterzan, P., Robuvit{\textregistered}: Improvement of fatigue in medical convalescence (2018) J. Sport. Med. Phys. Fit, 58, pp. 678-683. , 29719945; Weichmann, F., Avaltroni, F., Burki, C., Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit (2021) J. Med. Food, 24, pp. 897-907; Dini{\'c}, J., Ran{\d}elovi{\'c}, T., Stankovi{\'c}, T., Dragoj, M., Isakovi{\'c}, A., Novakovi{\'c}, M., Pe{\v s}i{\'c}, M., Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes (2015) Fitoterapia, 105, pp. 169-176. , 26162555; Krivoy, N., Pavlotzky, E., Chrubasik, S., Eisenberg, E., Brook, G., Effect of salicis cortex extract on human platelet aggregation (2001) Planta Med, 67, pp. 209-212. , 11345689; Schmid, B., L{\"u}dtke, R., Selbmann, H.K., K{\"o}tter, I., Tschirdewahn, B., Schaffner, W., Heide, L., Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: Randomized placebo-controlled, double blind clinical trial (2001) Phytother. Res, 15, pp. 344-350; Zhu, Z., Gao, S., Chen, C., Xu, W., Xiao, P., Chen, Z., Du, C., Wang, C., The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway (2022) Exp. Mol. Med, 54, pp. 1927-1939; Ebeling, S., Naumann, K., Pollok, S., Wardecki, T., Vidal-y-Sy, S., Nascimento, J.M., Boerries, M., Merfort, I., From a traditional medicinal plant to a rational drug: Understanding the clinically proven wound healing efficacy of birch bark extract (2014) PLoS ONE, 9; Daniels, R., Grysko, M., Evaluation of the mechanism of gelation of an oleogel based on a triterpene extract from the outer bark of birch (2013) Pharm. Int. J. Pharm. Sci, 68, pp. 572-577; Ghaffar, K.A., Daniels, R., Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives (2020) Pharmaceutics, 12. , 32098195; https://www.ema.europa.eu/en/medicines/human/EPAR/filsuvez\#authorisation-details-section, Available online; Hern{\'a}ndez, A.F., Gil, F., Lacasa{\~n}a, M., Toxicological interactions of pesticide mixtures: An update (2017) Arch. Toxicol, 91, pp. 3211-3223. , 28845507; Rasoanaivo, P., Wright, C.W., Willcox, M.L., Gilbert, B., Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions (2011) Malar. J, 10, p. S4; Sarkar, S., Artificial blood (2008) Indian J. Crit. Care Med, 12, pp. 140-144; Hofmann, T., Visi-Rajczi, E., Albert, L., Antioxidant properties assessment of the cones of conifers through the combined evaluation of multiple antioxidant assays (2020) Ind. Crops Prod, 145, p. 111935; Brennan, M., Fritsch, C., Cosgun, S., Dumarcay, S., Colin, F., G{\'e}rardin, P., Quantitative and qualitative composition of bark polyphenols changes longitudinally with bark maturity in Abies alba Mill (2020) Ann. For. Sci, 77, p. 9; Hubert, J., Angelis, A., Aligiannis, N., Rosalia, M., Abedini, A., Bakiri, A., Reynaud, R., Skaltsounis, A.-L., In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees (2016) Planta Med, 82, pp. 1351-1358; Michalak, M., Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process (2022) Int. J. Mol. Sci, 23; Hoang, H.T., Moon, J.-Y., Lee, Y.-C., Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives (2021) Cosmetics, 8; Hwang, D., Kim, H., Shin, H., Jeong, H., Kim, J., Kim, D., Cosmetic effects of Prunus padus bark extract (2014) Korean J. Chem. Eng, 31, pp. 2280-2285; Mian, M., Silfvast-Kaiser, A.S., Paek, S.Y., Kivelevitch, D., Menter, A., A Review of the Most Common Dermatologic Conditions and their Debilitating Psychosocial Impacts (2019) Int. Arch. Intern. Med, 3, p. 18; Bittner Fialov{\'a}, S., Rendekov{\'a}, K., Mu{\v c}aji, P., Nagy, M., Slobodn{\'i}kov{\'a}, L., Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine-A Review (2021) Int. J. Mol. Sci, 22; Tan, J., Beissert, S., Cook-Bolden, F., Chavda, R., Harper, J., Hebert, A., Lain, E., Weiss, J., Impact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey (2022) Am. J. Clin. Dermatol, 23, pp. 115-123. , 34705166; Forest Resources Assessment 2010: Global Tables, , http://www.earth-policy.org/?/indicators/C56/, Available online; K{\"o}ble, R., Seufert, G., Novel Maps for Forest Tree Species in Europe Proceedings of the 8th European Symposium on the Physico-Chemical Behaviour of Air Pollutants: A Changing Atmosphere, , Torino, Italy, 17–20 September 2001; San-Miguel-Ayanz, J., de Rigo, D., Caudullo, G., Durrant, T.H., Mauri, A., (2016) European Atlas of Forest Tree Species, 2016, , Publications Office of the European Union, Luxembourg; Feng, S., Cheng, S., Yuan, Z., Leitch, M., Xu, C., Valorization of bark for chemicals and materials: A review (2013) Renew. Sustain. Energy Rev, 26, pp. 560-578; Meindl, A., Grzybek, J., Petutschnigg, A., Schnabel, T., High purity lignin from untreated larch bark: An efficient green methodology for lignin valorization and low-value by-product mitigation (2022) J. Wood Chem. Technol, 42, pp. 235-243; Gruber, L., Seidl, L., Zanetti, M., Schnabel, T., Calorific Value and Ash Content of Extracted Birch Bark (2021) Forests, 12; Grzybek, J., Sepperer, T., Petutschnigg, A., Schnabel, T., Organosolv Lignin from European Tree Bark: Influence of Bark Pretreatment (2021) Materials, 14; Santos, M.B., Sillero, L., Gatto, D.A., Labidi, J., Bioactive molecules in wood extractives: Methods of extraction and separation, a review (2022) Ind. Crops Prod, 186, p. 115231; Zhang, Q.-W., Lin, L.-G., Ye, W.-C., Techniques for extraction and isolation of natural products: A comprehensive review (2018) Chin. Med, 13, p. 20; Mena-Garc{\'i}a, A., Ruiz-Matute, A.I., Soria, A.C., Sanz, M.L., Green techniques for extraction of bioactive carbohydrates (2019) TrAC Trends Anal. Chem, 119, p. 115612; Selvamuthukumaran, M., Shi, J., Recent advances in extraction of antioxidants from plant by-products processing industries (2017) Food Qual. Saf, 1, pp. 61-81; J{\"a}ger, S., Beffert, M., Hoppe, K., Nadberezny, D., Frank, B., Scheffler, A., Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example (2011) Sci. Pharm, 79, pp. 145-155; Ali, A., Chua, B.L., Chow, Y.H., An insight into the extraction and fractionation technologies of the essential oils and bioactive compounds in Rosmarinus officinalis L.: Past, present and future (2019) TrAC Trends Anal. Chem, 118, pp. 338-351; Chin, F.S., Chong, K.P., Markus, A., Wong, N.K., Tea polyphenols and alkaloids content using Soxhlet and direct extraction method (2013) World J. Agric. Sci, 9, pp. 266-270; Kumar, K., Srivastav, S., Sharanagat, V.S., Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review (2021) Ultrason. Sonochem, 70, p. 105325. , 32920300; Mandal, V., Mohan, Y., Hemalatha, S., Microwave Assisted Extraction-An Innovative and Promising Extraction Tool for Medicinal Plant Research (2007) Pharmacogn. Rev, 1, pp. 7-18; Zwingelstein, M., Draye, M., Besombes, J.-L., Piot, C., Chatel, G., Viticultural wood waste as a source of polyphenols of interest: Opportunities and perspectives through conventional and emerging extraction methods (2020) Waste Manag, 102, pp. 782-794; H{\"a}m{\"a}l{\"a}inen, H., Ruusunen, M., Identification of a Supercritical Fluid Extraction Process for Modelling the Energy Consumption (2021) SSRN J, 252, p. 124033; Ahmad, T., Masoodi, F.A., Rather, S.A., Wani, S.M., Gull, A.J., Supercritical Fluid Extraction: A Review (2019) J. Biol. Chem. Chron, 5, pp. 114-122; Patel, D.D., Lee, J.-M., Applications of ionic liquids (2012) Chem. Rec, 12, pp. 329-355; Singh, S.K., Solubility of lignin and chitin in ionic liquids and their biomedical applications (2019) Int. J. Biol. Macromol, 132, pp. 265-277; Choi, Y.H., Verpoorte, R., Green solvents for the extraction of bioactive compounds from natural products using ionic liquids and deep eutectic solvents (2019) Curr. Opin. Food Sci, 26, pp. 87-93; Yang, Z., Natural Deep Eutectic Solvents and Their Applications in Biotechnology (2019) Adv. Biochem. Eng. Biotechnol, 168, pp. 31-59; Liu, Y., Friesen, J.B., McAlpine, J.B., Lankin, D.C., Chen, S.-N., Pauli, G.F., Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives (2018) J. Nat. Prod, 81, pp. 679-690; Marathe, S.J., Jadhav, S.B., Bankar, S.B., Singhal, R.S., Enzyme-Assisted Extraction of Bioactives (2017) Food Bioactives, pp. 171-201. , Springer, Berlin/Heidelberg, Germany; Xia, Y., Wang, Y., Li, W., Ma, C., Liu, S., Homogenization-assisted cavitation hybrid rotation extraction and macroporous resin enrichment of dihydroquercetin from Larix gmelinii (2017) J. Chromatogr. B, 1070, pp. 62-69; Gligor, O., Mocan, A., Moldovan, C., Locatelli, M., Crișan, G., Ferreira, I.C., Enzyme-assisted extractions of polyphenols—A comprehensive review (2019) Trends Food Sci. Technol, 88, pp. 302-315; Wang, L., Weller, C.L., Recent advances in extraction of nutraceuticals from plants (2006) Trends Food Sci. Technol, 17, pp. 300-312; Chupin, L., Maunu, S.L., Reynaud, S., Pizzi, A., Charrier, B., Charrier-EL Bouhtoury, F., Microwave assisted extraction of maritime pine (Pinus pinaster) bark: Impact of particle size and characterization (2015) Ind. Crops Prod, 65, pp. 142-149; Jovanovi{\'c}, A.A., {\D}or{\d}evi{\'c}, V.B., Zduni{\'c}, G.M., Pljevljaku{\v s}i{\'c}, D.S., {\v S}avikin, K.P., Go{\d}evac, D.M., Bugarski, B.M., Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques (2017) Sep. Purif. Technol, 179, pp. 369-380; Li, H., Deng, Z., Wu, T., Liu, R., Loewen, S., Tsao, R., Microwave-assisted extraction of phenolics with maximal antioxidant activities in tomatoes (2012) Food Chem, 130, pp. 928-936; Asp{\'e}, E., Fern{\'a}ndez, K., The effect of different extraction techniques on extraction yield, total phenolic, and anti-radical capacity of extracts from Pinus radiata Bark (2011) Ind. Crops Prod, 34, pp. 838-844; Schreck, R., Baeuerle, P.A., A role for oxygen radicals as second messengers (1991) Trends Cell Biol, 1, pp. 39-42; Wang, H., Kochevar, I.E., Involvement of UVB-induced reactive oxygen species in TGF-beta biosynthesis and activation in keratinocytes (2005) Free. Radic. Biol. Med, 38, pp. 890-897. , 15749385; Maya-Cano, D.A., Arango-Varela, S., Santa-Gonzalez, G.A., Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity (2021) Heliyon, 7; Naidoo, K., Birch-Machin, M., Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) Cosmetics, 4; Tr{\"u}eb, R.M., Oxidative stress and its impact on skin, scalp and hair (2021) Int. J. Cosmet. Sci, 43, pp. S9-S13. , 34424547; Halliwell, B., Gutteridge, J.M.C., (2015) Free Radicals in Biology and Medicine, , Oxford University Press, Oxford, UK; Young, I.S., Woodside, J.V., Antioxidants in health and disease (2001) J. Clin. Pathol, 54, pp. 176-186. , 11253127; Miro{\'n}czuk-Chodakowska, I., Witkowska, A.M., Zujko, M.E., Endogenous non-enzymatic antioxidants in the human body (2018) Adv. Med. Sci, 63, pp. 68-78; Ahmad, P., Jaleel, C.A., Salem, M.A., Nabi, G., Sharma, S., Roles of enzymatic and nonenzymatic antioxidants in plants during abiotic stress (2010) Crit. Rev. Biotechnol, 30, pp. 161-175; Sulaiman, M., An Overview of Natural Plant Antioxidants: Analysis and Evaluation (2013) Adv. Biochem, 1, p. 64; Gasc{\'o}n, S., Jim{\'e}nez-Moreno, N., Jim{\'e}nez, S., Quero, J., Rodr{\'i}guez-Yoldi, M.J., Anc{\'i}n-Azpilicueta, C., Nutraceutical composition of three pine bark extracts and their antiproliferative effect on Caco-2 cells (2018) J. Funct. Foods, 48, pp. 420-429; Skrypnik, L., Grigorev, N., Michailov, D., Antipina, M., Danilova, M., Pungin, A., Comparative study on radical scavenging activity and phenolic compounds content in water bark extracts of alder (Alnus glutinosa (L.) Gaertn.), oak (Quercus robur L.) and pine (Pinus sylvestris L.) (2019) Eur. J. Wood Prod, 77, pp. 879-890; Agarwal, C., Hofmann, T., Visi-Rajczi, E., P{\'a}sztory, Z., Low-frequency, green sonoextraction of antioxidants from tree barks of Hungarian woodlands for potential food applications (2021) Chem. Eng. Process. Process Intensif, 159, p. 108221; Emrich, S., Schuster, A., Schnabel, T., Oostingh, G.J., Antimicrobial Activity and Wound-Healing Capacity of Birch, Beech and Larch Bark Extracts (2022) Molecules, 27; Hofmann, T., Nebehaj, E., Stefanovits-B{\'a}nyai, {\'E}., Albert, L., Antioxidant capacity and total phenol content of beech (Fagus sylvatica L.) bark extracts (2015) Ind. Crops Prod, 77, pp. 375-381; Sillero, L., Prado, R., Labidi, J., Optimization of different extraction methods to obtaining bioactive compounds from larix decidua bark (2018) Chem. Eng. Trans, 70, pp. 1369-1374; Sillero, L., Prado, R., Labidi, J., Simultaneous microwave-ultrasound assisted extraction of bioactive compounds from bark (2020) Chem. Eng. Process. Process Intensif, 156, p. 108100; Singh, G., Passsari, A.K., Leo, V.V., Mishra, V.K., Subbarayan, S., Singh, B.P., Kumar, B., Lalhlenmawia, H., Evaluation of Phenolic Content Variability along with Antioxidant, Antimicrobial, and Cytotoxic Potential of Selected Traditional Medicinal Plants from India (2016) Front. Plant Sci, 7, p. 407. , 27066046; Dudonn{\'e}, S., Vitrac, X., Couti{\`e}re, P., Woillez, M., M{\'e}rillon, J.-M., Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays (2009) J. Agric. Food Chem, 57, pp. 1768-1774. , 19199445; Niroula, A., Khatri, S., Khadka, D., Timilsina, R., Total phenolic contents and antioxidant activity profile of selected cereal sprouts and grasses (2019) Int. J. Food Prop, 22, pp. 427-437; Piluzza, G., Bullitta, S., Correlations between phenolic content and antioxidant properties in twenty-four plant species of traditional ethnoveterinary use in the Mediterranean area (2011) Pharm. Biol, 49, pp. 240-247; Kumar, S., Krishna Chaitanya, R., Preedy, V.R., Assessment of Antioxidant Potential of Dietary Components (2018) HIV/AIDS, pp. 239-253. , Academic Press, Cambridge, MA, USA, Chapter 20; Dalle-Donne, I., Rossi, R., Giustarini, D., Milzani, A., Colombo, R., Protein carbonyl groups as biomarkers of oxidative stress (2003) Clin. Chim. Acta Int. J. Clin. Chem, 329, pp. 23-38; Wehr, N.B., Levine, R.L., (2013) Quantification of Protein Carbonylation. Cell Senescence, pp. 265-281. , Humana Press, Totowa, NJ, USA; Zitka, O., Skalickova, S., Gumulec, J., Masarik, M., Adam, V., Hubalek, J., Trnkova, L., Kizek, R., Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients (2012) Oncol. Lett, 4, pp. 1247-1253; Jaganjac, M., Sredoja Tisma, V., Zarkovic, N., Short Overview of Some Assays for the Measurement of Antioxidant Activity of Natural Products and Their Relevance in Dermatology (2021) Molecules, 26; Agarwal, C., Hofmann, T., Vr{\v s}ansk{\'a}, M., Schlosserov{\'a}, N., Visi-Rajczi, E., Vob{\v e}rkov{\'a}, S., P{\'a}sztory, Z., In vitro antioxidant and antibacterial activities with polyphenolic profiling of wild cherry, the European larch and sweet chestnut tree bark (2021) Eur. Food Res. Technol, 247, pp. 2355-2370; Polka, D., Pods{\c e}dek, A., Kozio{\l}kiewicz, M., Comparison of Chemical Composition and Antioxidant Capacity of Fruit, Flower and Bark of Viburnum opulus (2019) Plant Foods Hum. Nutr, 74, pp. 436-442; Siddhuraju, P., Studies on the antioxidant activity of Indian Laburnum (Cassia fistula L.): A preliminary assessment of crude extracts from stem bark, leaves, flowers and fruit pulp (2002) Food Chem, 79, pp. 61-67; Khan, M.A., Rahman, A.A., Islam, S., Khandokhar, P., Parvin, S., Islam, M.B., Hossain, M., Nasrin, S., A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae) (2013) BMC Res. Notes, 6. , 23331970; Dr{\'o}{\.z}d{\.z}, P., Pyrzynska, K., Assessment of polyphenol content and antioxidant activity of oak bark extracts (2018) Eur. J. Wood Prod, 76, pp. 793-795; Garc{\'i}a-P{\'e}rez, M.-E., Royer, M., Duque-Fernandez, A., Diouf, P.N., Stevanovic, T., Pouliot, R., Antioxidant, toxicological and antiproliferative properties of Canadian polyphenolic extracts on normal and psoriatic keratinocytes (2010) J. Ethnopharmacol, 132, pp. 251-258; Touri{\~n}o, S., Selga, A., Jim{\'e}nez, A., Juli{\'a}, L., Lozano, C., Liz{\'a}rraga, D., Cascante, M., Torres, J.L., Procyanidin fractions from pine (Pinus pinaster) bark: Radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells (2005) J. Agric. Food Chem, 53, pp. 4728-4735. , 15941307; Lee, K.W., Kim, Y.J., Kim, D.-O., Lee, H.J., Lee, C.Y., Major phenolics in apple and their contribution to the total antioxidant capacity (2003) J. Agric. Food Chem, 51, pp. 6516-6520. , 14558772; Sutcliffe, T.C., Winter, A.N., Punessen, N.C., Linseman, D.A., Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress (2017) Antioxidants, 6. , 29027929; Rodr{\'i}guez-Ramiro, I., Ramos, S., Bravo, L., Goya, L., Mart{\'i}n, M.{\'A}., Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway (2011) J. Nutr. Biochem, 22, pp. 1186-1194. , 21334869; Marini, A., Grether-Beck, S., Jaenicke, T., Weber, M., Burki, C., Formann, P., Brenden, H., Krutmann, J., Pycnogenol{\textregistered} effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women (2012) Skin Pharmacol. Physiol, 25, pp. 86-92. , 22270036; Furumura, M., Sato, N., Kusaba, N., Takagaki, K., Nakayama, J., Oral administration of French maritime pine bark extract (Flavangenol({\textregistered})) improves clinical symptoms in photoaged facial skin (2012) Clin. Interv. Aging, 7, pp. 275-286; Saliou, C., Rimbach, G., Moini, H., McLaughlin, L., Hosseini, S., Lee, J., Watson, R.R., Packer, L., Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract (2001) Free Radic. Biol. Med, 30, pp. 154-160; Zhao, H., Wu, J., Wang, N., Grether-Beck, S., Krutmann, J., Wei, L., Oral Pycnogenol{\textregistered} Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study (2021) Skin Pharmacol. Physiol, 34, pp. 135-145; Kimura, Y., Sumiyoshi, M., French maritime pine bark (Pinus maritima Lam.) extract (Flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice (2010) Photochem. Photobiol, 86, pp. 955-963; Brizi, C., Santulli, C., Micucci, M., Budriesi, R., Chiarini, A., Aldinucci, C., Frosini, M., Neuroprotective Effects of Castanea sativa Mill. Bark Extract in Human Neuroblastoma Cells Subjected to Oxidative Stress (2016) J. Cell. Biochem, 117, pp. 510-520; Ishikado, A., Sono, Y., Matsumoto, M., Robida-Stubbs, S., Okuno, A., Goto, M., King, G.L., Makino, T., Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans (2013) Free Radic. Biol. Med, 65, pp. 1506-1515; He, F., Ru, X., Wen, T., NRF2, a Transcription Factor for Stress Response and Beyond (2020) Int. J. Mol. Sci, 21. , 32640524; Tonelli, C., Chio, I.I.C., Tuveson, D.A., Transcriptional Regulation by Nrf2 (2018) Antioxid. Redox Signal, 29, pp. 1727-1745. , 28899199; Xian, D., Guo, M., Xu, J., Yang, Y., Zhao, Y., Zhong, J., Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses (2021) Redox Rep, 26, pp. 134-146. , 34355664; Nachbar, F., Korting, H.C., The role of vitamin E in normal and damaged skin (1995) J. Mol. Med, 73, pp. 7-17; Choubey, V., Sarkar, R., Garg, V., Kaushik, S., Ghunawat, S., Sonthalia, S., Role of oxidative stress in melasma: A prospective study on serum and blood markers of oxidative stress in melasma patients (2017) Int. J. Dermatol, 56, pp. 939-943; Ji, H., Li, X.-K., Oxidative Stress in Atopic Dermatitis (2016) Oxidative Med. Cell. Longev, 2016, p. 2721469; Sarici, G., Cinar, S., Armutcu, F., Altinyazar, C., Koca, R., Tekin, N.S., Oxidative stress in acne vulgaris (2010) J. Eur. Acad. Dermatol. Venereol, 24, pp. 763-767; Kaur, S., Zilmer, K., Leping, V., Zilmer, M., Allergic contact dermatitis is associated with significant oxidative stress (2014) Dermatol. Res. Pract, 2014, p. 415638; Emre, S., Metin, A., Demirseren, D.D., Akoglu, G., Oztekin, A., Neselioglu, S., Erel, O., The association of oxidative stress and disease activity in seborrheic dermatitis (2012) Arch. Dermatol. Res, 304, pp. 683-687; Acharya, P., Mathur, M.C., Oxidative stress in alopecia areata: A systematic review and meta-analysis (2020) Int. J. Dermatol, 59, pp. 434-440; Tisma, V.S., Basta-Juzbasic, A., Jaganjac, M., Brcic, L., Dobric, I., Lipozencic, J., Tatzber, F., Poljak-Blazi, M., Oxidative stress and ferritin expression in the skin of patients with rosacea (2009) J. Am. Acad. Dermatol, 60, pp. 270-276; Yang, L., Xian, D., Xiong, X., Lai, R., Song, J., Zhong, J., Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications (2018) BioMed Res. Int, 2018, p. 8584136. , 29750172; Chaiprasongsuk, A., Panich, U., Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2 (2022) Front. Pharmacol, 13, p. 823881. , 35645796; Klemow, K.M., Bartlow, A., Crawford, J., Kocher, N., Shah, J., Ritsick, M., (2011) Herbal Medicine: Biomolecular and Clinical Aspects, , Shenefelt P.D., (ed), 2nd ed., CRC Press/Taylor \& Francis, Abingdon, UK; Park, C., Park, J., Kim, W.-J., Kim, W., Cheong, H., Kim, S.-J., Malonic Acid Isolated from Pinus densiflora Inhibits UVB-Induced Oxidative Stress and Inflammation in HaCaT Keratinocytes (2021) Polymers, 13; Parzonko, A., Kiss, A.K., Caffeic acid derivatives isolated from Galinsoga parviflora herb protected human dermal fibroblasts from UVA-radiation (2019) Phytomedicine, 57, pp. 215-222; Ni, Z., Mu, Y., Gulati, O., Treatment of melasma with Pycnogenol (2002) Phytother. Res, 16, pp. 567-571; Garc{\'i}a-P{\'e}rez, M.-E., Allaeys, I., Rusu, D., Pouliot, R., Janezic, T.S., Poubelle, P.E., Picea mariana polyphenolic extract inhibits phlogogenic mediators produced by TNF-α-activated psoriatic keratinocytes: Impact on NF-κB pathway (2014) J. Ethnopharmacol, 151, pp. 265-278; Smiljanic, S., Messaraa, C., Lafon-Kolb, V., Hrapovic, N., Amini, N., Osterlund, C., Visdal-Johnsen, L., Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits (2022) Int. J. Mol. Sci, 23. , 36293365; Terreni, M., Taccani, M., Pregnolato, M., New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives (2021) Molecules, 26. , 34063264; Pan, S.-Y., Litscher, G., Gao, S.-H., Zhou, S.-F., Yu, Z.-L., Chen, H.-Q., Zhang, S.-F., Ko, K.-M., Historical perspective of traditional indigenous medical practices: The current renaissance and conservation of herbal resources (2014) Evid.-Based Complement. Altern. Med, 2014, p. 525340; Barbieri, R., Coppo, E., Marchese, A., Daglia, M., Sobarzo-S{\'a}nchez, E., Nabavi, S.F., Nabavi, S.M., Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity (2017) Microbiol. Res, 196, pp. 44-68; Miklasi{\'n}ska-Majdanik, M., K{\c e}pa, M., Wojtyczka, R.D., Idzik, D., W{\c a}sik, T.J., Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains (2018) Int. J. Environ. Res. Public Health, 15; Park, K.D., Cho, S.J., Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: Improvement of stability and proposed action mechanism (2010) Eur. J. Med. Chem, 45, pp. 1028-1033; Kang, S.S., Kim, J.-G., Lee, T.-H., Oh, K.-B., Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen (2006) Biol. Pharm. Bull, 29, pp. 1751-1755; Lin, R.-D., Chin, Y.-P., Hou, W.-C., Lee, M.-H., The effects of antibiotics combined with natural polyphenols against clinical methicillin-resistant Staphylococcus aureus (MRSA) (2008) Planta Med, 74, pp. 840-846; Zhao, W.-H., Hu, Z.-Q., Hara, Y., Shimamura, T., Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus (2002) Antimicrob. Agents Chemother, 46, pp. 2266-2268; Qin, R., Xiao, K., Li, B., Jiang, W., Peng, W., Zheng, J., Zhou, H., The combination of catechin and epicatechin callate from Fructus Crataegi potentiates beta-lactam antibiotics against methicillin-resistant staphylococcus aureus (MRSA) in vitro and in vivo (2013) Int. J. Mol. Sci, 14, pp. 1802-1821; Balouiri, M., Sadiki, M., Ibnsouda, S.K., Methods for in vitro evaluating antimicrobial activity: A review (2016) J. Pharm. Anal, 6, pp. 71-79; Valgas, C., de Souza, S.M., Sm{\^a}nia, E.F.A., Sm{\^a}nia, A., Jr., Screening methods to determine antibacterial activity of natural products (2007) Braz. J. Microbiol, 38, pp. 369-380; Morales, D., Oak trees (Quercus spp.) as a source of extracts with biological activities: A narrative review (2021) Trends Food Sci. Technol, 109, pp. 116-125; Tanase, C., Nicolescu, A., Nisca, A., Ștef{\u a}nescu, R., Babot{\u a}, M., Mare, A.D., Ciurea, C.N., Man, A., Biological Activity of Bark Extracts from Northern Red Oak (Quercus rubra L.): An Antioxidant, Antimicrobial and Enzymatic Inhibitory Evaluation (2022) Plants, 11; Andrensek, S., Simonovska, B., Vovk, I., Fyhrquist, P., Vuorela, H., Vuorela, P., Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom (2004) Int. J. Food Microbiol, 92, pp. 181-187; Neiva, D.M., Lu{\'i}s, {\^A}., Gominho, J., Domingues, F., Duarte, A.P., Pereira, H., Bark residues valorization potential regarding antioxidant and antimicrobial extracts (2020) Wood Sci. Technol, 54, pp. 559-585; Ferrentino, G., Haman, N., Morozova, K., Tonon, G., Scampicchio, M., Phenolic compounds extracted from spruce (Picea abies) by supercritical carbon dioxide as antimicrobial agents against gram-positive bacteria assessed by isothermal calorimetry (2021) J. Anal. Calorim, 145, pp. 3093-3103; {\v Z}ivkovi{\'c}, J., Zekovi{\'c}, Z., Muji{\'c}, I., Vidovi{\'c}, S., Cvetkovi{\'c}, D., Lepojevi{\'c}, {\v Z}., Nikoli{\'c}, G., Truti{\'c}, N., Scavenging capacity of superoxide radical and screening of antimicrobial activity of Castanea sativa Mill. extracts (2010) Czech J. Food Sci, 28, pp. 61-68; Tanase, C., Cosarca, S., Toma, F., Mare, A., Man, A., Miklos, A., Imre, S., Boz, I., Antibacterial activities of beech bark (Fagus sylvatica L.) polyphenolic extract (2018) Environ. Eng. Manag. J, 17, pp. 877-884; Laireiter, C.M., Schnabel, T., K{\"o}ck, A., Stalzer, P., Petutschnigg, A., Oostingh, G.J., Hell, M., Active Anti-Microbial Effects of Larch and Pine Wood on Four Bacterial Strains (2013) BioResources, 9, pp. 273-281; Duric, K., Kovac-Besovic, E., Niksic, H., Sofic, E., Antibacterial Activity of Methanolic Extracts, Decoction and Isolated Triterpene Products from Different Parts of Birch, Betula pendula, Roth (2013) J. Plant Stud, 2, p. 61; Torras, M.A.C., Faura, C.A., Sch{\"o}nlau, F., Rohdewald, P., Antimicrobial activity of Pycnogenol (2005) Phytother. Res, 19, pp. 647-648; Keita, K., Darkoh, C., Okafor, F., Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens (2022) SN Appl. Sci, 4, p. 209; Byrd, A.L., Belkaid, Y., Segre, J.A., The human skin microbiome (2018) Nat. Rev. Microbiol, 16, pp. 143-155. , 29332945; Nasri, H., Bahmani, M., Shahinfard, N., Moradi Nafchi, A., Saberianpour, S., Rafieian Kopaei, M., Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences (2015) Jundishapur J. Microbiol, 8, p. e25580; Mayslich, C., Grange, P.A., Dupin, N., Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors (2021) Microorganisms, 9. , 33540667; Dreno, B., Thiboutot, D., Gollnick, H., Bettoli, V., Kang, S., Leyden, J.J., Shalita, A., Torres, V., Antibiotic stewardship in dermatology: Limiting antibiotic use in acne (2014) Eur. J. Dermatol, 24, pp. 330-334; Ayaz, M., Ullah, F., Sadiq, A., Ullah, F., Ovais, M., Ahmed, J., Devkota, H.P., Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance (2019) Chem. Biol. Interact, 308, pp. 294-303. , 31158333; Suntar, I., Sarker, S.D., Nahar, L., Basar, N., Traditional Medicine for Wound Management (2017) Evid.-Based Complement. Altern. Med, 2017, p. 4214382; Wilkinson, H.N., Hardman, M.J., Wound healing: Cellular mechanisms and pathological outcomes (2020) Open Biol, 10, p. 200223; Carvalho, M.T.B., Ara{\'u}jo-Filho, H.G., Barreto, A.S., Quintans-J{\'u}nior, L.J., Quintans, J.S.S., Barreto, R.S.S., Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action (2021) Phytomedicine, 90, p. 153636; Vitale, S., Colanero, S., Placidi, M., Di Emidio, G., Tatone, C., Amicarelli, F., D{\textquoteright}Alessandro, A.M., Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research (2022) Molecules, 27; Mosae Selvakumar, P., Plant-Derived Compounds for Wound Healing—A Review (2018) Org. Med. Chem. Int. J, 5, pp. 13-17; Maleki, S.J., Crespo, J.F., Cabanillas, B., Anti-inflammatory effects of flavonoids (2019) Food Chem, 299, p. 125124; Singh, W.R., Devi, H.S., Kumawat, S., Sadam, A., Appukuttan, A.V., Patel, M.R., Lingaraju, M.C., Kumar, D., Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats (2019) Eur. J. Pharmacol, 858, p. 172466. , 31220437; Lazaro, J.L., Izzo, V., Meaume, S., Davies, A.H., Lobmann, R., Uccioli, L., Elevated levels of matrix metalloproteinases and chronic wound healing: An updated review of clinical evidence (2016) J. Wound Care, 25, pp. 277-287; https://www.ema.europa.eu/en/medicines/human/EPAR/episalvan\#overview-section, Available online; Scheffler, A., The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside (2019) Planta Med, 85, pp. 524-527. , 30856673; Haque, S., Nawrot, D.A., Alakurtti, S., Ghemtio, L., Yli-Kauhaluoma, J., Tammela, P., Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives (2014) PLoS ONE, 9. , 25032708; Schwieger-Briel, A., Ott, H., Kiritsi, D., Laszczyk-Lauer, M., Bodemer, C., Mechanism of Oleogel-S10: A triterpene preparation for the treatment of epidermolysis bullosa (2019) Dermatol. Ther, 32, p. e12983. , 31168940; Kindler, S., Schuster, M., Seebauer, C., Rutkowski, R., Hauschild, A., Podmelle, F., Metelmann, C., Metelmann, H.-R., Triterpenes for Well-Balanced Scar Formation in Superficial Wounds (2016) Molecules, 21. , 27618886; Dehelean, C.A., Soica, C., Lede{\c t}i, I., Alua{\c s}, M., Zupko, I., Gǎlu{\c s}can, A., Cinta-Pinzaru, S., Munteanu, M., Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation (2012) Chem. Cent. J, 6, p. 137; Huyke, C., Laszczyk, M., Scheffler, A., Ernst, R., Schempp, C.M., Behandlung aktinischer Keratosen mit Birkenkorkextrakt: Eine Pilotstudie (2006) J. Dtsch. Dermatol. Ges, 4, pp. 132-136; Hemida, H., Doukani, K., Zitouni, A., Miloud, B., Beggar, H., Bouhenni, H., Assessment of wound healing activity of ethanolic extracts of Pistacia lentiscus L. leaves and Quercus ilex L. bark in full thickness skin excision in rats (2022) Adv. Tradit. Med, 22, pp. 589-597; Secim-Karakaya, P., Saglam-Metiner, P., Yesil-Celiktas, O., Antimicrobial and wound healing properties of cotton fabrics functionalized with oil-in-water emulsions containing Pinus brutia bark extract and Pycnogenol{\textregistered} for biomedical applications (2021) Cytotechnology, 73, pp. 423-431; Yesİl-Celİktas, O., A comparative study of antioxidant properties of extracts obtained from renewable forestry and agricultural resources (2009) Fresenius Environ. Bull, 18, pp. 1507-1512; Iravani, S., Zolfaghari, B., Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract (2011) Res. Pharm. Sci, 6, pp. 1-11; Weyns, A.-S., Verlaet, A.A., van Herreweghe, M., Breynaert, A., Fransen, E., de Meester, I., Logie, E., van West, D., Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 2: Oxidative Stress and Immunological Modulation (2022) J. Funct. Foods, 97, p. 105247; Cretu, E., Karonen, M., Salminen, J.-P., Mircea, C., Trifan, A., Charalambous, C., Constantinou, A.I., Miron, A., In vitro study on the antioxidant activity of a polyphenol-rich extract from Pinus brutia bark and its fractions (2013) J. Med. Food, 16, pp. 984-991; Angelis, A., Hubert, J., Aligiannis, N., Michalea, R., Abedini, A., Nuzillard, J.-M., Gangloff, S.C., Renault, J.-H., Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties (2016) Molecules, 21; Coșarc{\u a}, S.-L., Moac{\u a}, E.-A., Tanase, C., Muntean, D.L., Pavel, I.Z., Dehelean, C.A., Spruce and beech bark aqueous extracts: Source of polyphenols, tannins and antioxidants correlated to in vitro antitumor potential on two different cell lines (2019) Wood Sci. Technol, 53, pp. 313-333; Tanase, C., Mocan, A., Coșarc{\u a}, S., Gavan, A., Nicolescu, A., Gheldiu, A.-M., Vodnar, D.C., Crișan, O., Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties (2019) Antioxidants, 8; Abyshev, A.Z., Agaev, {\'E}.M., Guseinov, A.B., Studies of the chemical composition of birch bark extracts (Cortex betula) from the Betulaceae family (2007) Pharm. Chem. J, 41, pp. 419-423; Preda, M., Cheveresan, A., Pinzaru, I., Dobrescu, A., Pavel, I.Z., Vlaia, V., Sisu, E., Chemical Composition and Biological Activity of Birch Bark Extracts on Human and Murine Healthy/Melanoma Cell Lines (2018) Rev. Chim, 69, pp. 1907-1910; Bito, T., Roy, S., Sen, C.K., Packer, L., Pine bark extract pycnogenol downregulates IFN-γ-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression (2000) Free Radic. Biol. Med, 28, pp. 219-227. , 11281289; Smailagi{\'c}, A., Ristivojevi{\'c}, P., Dimki{\'c}, I., Pavlovi{\'c}, T., Dabi{\'c} Zagorac, D., Veljovi{\'c}, S., Fotiri{\'c} Ak{\v s}i{\'c}, M., Nati{\'c}, M., Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts (2020) Foods, 9. , 32164204; Sulaiman, G.M., Hussien, N.N., Marzoog, T.R., Awad, H.A., Phenolic content, antioxidant, antimicrobial and cytotoxic activities of ethanolic extract of salix alba (2013) Am. J. Biochem. Biotechnol, 9, pp. 41-46; Tienaho, J., Reshamwala, D., Sarjala, T., Kilpel{\"a}inen, P., Liimatainen, J., Dou, J., Viher{\"a}-Aarnio, A., Jyske, T., Salix spp. Bark Hot Water Extracts Show Antiviral, Antibacterial, and Antioxidant Activities-The Bioactive Properties of 16 Clones (2021) Front. Bioeng. Biotechnol, 9, p. 797939. , 34976988",

year = "2023",

month = jan,

day = "9",

doi = "10.3390/antibiotics12010130",

language = "English",

volume = "12",

pages = "130",

journal = "Antibiotics",

issn = "2079-6382",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

TY - JOUR

T1 - Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications

AU - Häsler Gunnarsdottir, S.

AU - Sommerauer, L.

AU - Schnabel, T.

AU - Oostingh, G.J.

AU - Schuster, A.

N1 - Cited By :1 Export Date: 14 December 2023 Correspondence Address: Schuster, A.; Biomedical Sciences, Urstein Sued 1, Austria; email: [email protected] Chemicals/CAS: glutathione, 70-18-8; malonaldehyde, 542-78-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; thiobarbituric acid, 504-17-6 Funding text 1: This research was funded by a local research funding of the county of Salzburg, grant number 7081032 and the APC was funded by a local research funding of the county of Salzburg, grant number 7015130. References: Tudor, E.M., Huber, H., Bauprodukte aus Rinde (2022) Bauphysik Kalender 2022, pp. 139-169. , Fouad N.A., (ed), Wiley, Hoboken, NJ, USA; Cincinelli, A., Guerranti, C., Martellini, T., Scodellini, R., Residential wood combustion and its impact on urban air quality in Europe (2019) Curr. Opin. Environ. Sci. Health, 8, pp. 10-14; Ramage, M.H., Burridge, H., Busse-Wicher, M., Fereday, G., Reynolds, T., Shah, D.U., Wu, G., Densley-Tingley, D., The wood from the trees: The use of timber in construction (2017) Renew. Sustain. Energy Rev, 68, pp. 333-359; Gejdoš, M., Suchomel, J., Potential, Prices and Resources of Raw Wood Assortments for the Pulp and Paper Industry in Central Europe (2016) Key Eng. Mater, 688, pp. 210-217; Gordić, D., Babić, M., Jelić, D., Konćalović, D., Vukašinović, V., Integrating energy and environmental management in wood furniture industry (2014) Sci. World J, 2014, p. 596958. , 24587734; Pásztory, Z., Mohácsiné, I.R., Gorbacheva, G., Börcsök, Z., The utilization of tree bark (2016) BioResources, 11, pp. 7859-7888; Lee, E.L., Richards, N., Harrison, J., Barnes, J., Prevalence of Use of Traditional, Complementary and Alternative Medicine by the General Population: A Systematic Review of National Studies Published from 2010 to 2019 (2022) Drug Saf, 45, pp. 713-735; Forrai, J., (2011) History of Different Therapeutics of Venereal Disease Before the Discovery of Penicillin, , InTech Open, London, UK; Zhao, J., Zhao, Y., Chen, W., Li, Y.-M., Bian, X.-W., The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8 (2008) Anticancer Drugs, 19, pp. 713-719. , 18594213; Sarkar, A., Datta, P., Das, A.K., Gomes, A., Anti-rheumatoid and anti-oxidant activity of homeopathic Guaiacum officinale in an animal model (2014) Homeopathy, 103, pp. 133-138; Taib, M., Rezzak, Y., Bouyazza, L., Lyoussi, B., Medicinal Uses, Phytochemistry, and Pharmacological Activities of Quercus Species (2020) Evid.-Based Complement. Altern. Med, 2020, p. 1920683; Fraga-Corral, M., Otero, P., Cassani, L., Echave, J., Garcia-Oliveira, P., Carpena, M., Chamorro, F., Simal-Gandara, J., Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility (2021) Foods, 10; Belcaro, G., Hosoi, M., Feragalli, B., Luzzi, R., Dugall, M., Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress (2018) Minerva Med, 109, pp. 211-217. , 29164838; Ippolito, E., Belcaro, G., Luzzi, R., Hosoi, M., Dugall, M., Rohdewald, P., Feragalli, B., Peterzan, P., Robuvit®: Improvement of fatigue in medical convalescence (2018) J. Sport. Med. Phys. Fit, 58, pp. 678-683. , 29719945; Weichmann, F., Avaltroni, F., Burki, C., Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit (2021) J. Med. Food, 24, pp. 897-907; Dinić, J., Ranđelović, T., Stanković, T., Dragoj, M., Isaković, A., Novaković, M., Pešić, M., Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes (2015) Fitoterapia, 105, pp. 169-176. , 26162555; Krivoy, N., Pavlotzky, E., Chrubasik, S., Eisenberg, E., Brook, G., Effect of salicis cortex extract on human platelet aggregation (2001) Planta Med, 67, pp. 209-212. , 11345689; Schmid, B., Lüdtke, R., Selbmann, H.K., Kötter, I., Tschirdewahn, B., Schaffner, W., Heide, L., Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: Randomized placebo-controlled, double blind clinical trial (2001) Phytother. Res, 15, pp. 344-350; Zhu, Z., Gao, S., Chen, C., Xu, W., Xiao, P., Chen, Z., Du, C., Wang, C., The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway (2022) Exp. Mol. Med, 54, pp. 1927-1939; Ebeling, S., Naumann, K., Pollok, S., Wardecki, T., Vidal-y-Sy, S., Nascimento, J.M., Boerries, M., Merfort, I., From a traditional medicinal plant to a rational drug: Understanding the clinically proven wound healing efficacy of birch bark extract (2014) PLoS ONE, 9; Daniels, R., Grysko, M., Evaluation of the mechanism of gelation of an oleogel based on a triterpene extract from the outer bark of birch (2013) Pharm. Int. J. Pharm. Sci, 68, pp. 572-577; Ghaffar, K.A., Daniels, R., Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives (2020) Pharmaceutics, 12. , 32098195; https://www.ema.europa.eu/en/medicines/human/EPAR/filsuvez#authorisation-details-section, Available online; Hernández, A.F., Gil, F., Lacasaña, M., Toxicological interactions of pesticide mixtures: An update (2017) Arch. Toxicol, 91, pp. 3211-3223. , 28845507; Rasoanaivo, P., Wright, C.W., Willcox, M.L., Gilbert, B., Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions (2011) Malar. J, 10, p. S4; Sarkar, S., Artificial blood (2008) Indian J. Crit. Care Med, 12, pp. 140-144; Hofmann, T., Visi-Rajczi, E., Albert, L., Antioxidant properties assessment of the cones of conifers through the combined evaluation of multiple antioxidant assays (2020) Ind. Crops Prod, 145, p. 111935; Brennan, M., Fritsch, C., Cosgun, S., Dumarcay, S., Colin, F., Gérardin, P., Quantitative and qualitative composition of bark polyphenols changes longitudinally with bark maturity in Abies alba Mill (2020) Ann. For. Sci, 77, p. 9; Hubert, J., Angelis, A., Aligiannis, N., Rosalia, M., Abedini, A., Bakiri, A., Reynaud, R., Skaltsounis, A.-L., In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees (2016) Planta Med, 82, pp. 1351-1358; Michalak, M., Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process (2022) Int. J. Mol. Sci, 23; Hoang, H.T., Moon, J.-Y., Lee, Y.-C., Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives (2021) Cosmetics, 8; Hwang, D., Kim, H., Shin, H., Jeong, H., Kim, J., Kim, D., Cosmetic effects of Prunus padus bark extract (2014) Korean J. Chem. Eng, 31, pp. 2280-2285; Mian, M., Silfvast-Kaiser, A.S., Paek, S.Y., Kivelevitch, D., Menter, A., A Review of the Most Common Dermatologic Conditions and their Debilitating Psychosocial Impacts (2019) Int. Arch. Intern. Med, 3, p. 18; Bittner Fialová, S., Rendeková, K., Mučaji, P., Nagy, M., Slobodníková, L., Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine-A Review (2021) Int. J. Mol. Sci, 22; Tan, J., Beissert, S., Cook-Bolden, F., Chavda, R., Harper, J., Hebert, A., Lain, E., Weiss, J., Impact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey (2022) Am. J. Clin. Dermatol, 23, pp. 115-123. , 34705166; Forest Resources Assessment 2010: Global Tables, , http://www.earth-policy.org/?/indicators/C56/, Available online; Köble, R., Seufert, G., Novel Maps for Forest Tree Species in Europe Proceedings of the 8th European Symposium on the Physico-Chemical Behaviour of Air Pollutants: A Changing Atmosphere, , Torino, Italy, 17–20 September 2001; San-Miguel-Ayanz, J., de Rigo, D., Caudullo, G., Durrant, T.H., Mauri, A., (2016) European Atlas of Forest Tree Species, 2016, , Publications Office of the European Union, Luxembourg; Feng, S., Cheng, S., Yuan, Z., Leitch, M., Xu, C., Valorization of bark for chemicals and materials: A review (2013) Renew. Sustain. Energy Rev, 26, pp. 560-578; Meindl, A., Grzybek, J., Petutschnigg, A., Schnabel, T., High purity lignin from untreated larch bark: An efficient green methodology for lignin valorization and low-value by-product mitigation (2022) J. Wood Chem. Technol, 42, pp. 235-243; Gruber, L., Seidl, L., Zanetti, M., Schnabel, T., Calorific Value and Ash Content of Extracted Birch Bark (2021) Forests, 12; Grzybek, J., Sepperer, T., Petutschnigg, A., Schnabel, T., Organosolv Lignin from European Tree Bark: Influence of Bark Pretreatment (2021) Materials, 14; Santos, M.B., Sillero, L., Gatto, D.A., Labidi, J., Bioactive molecules in wood extractives: Methods of extraction and separation, a review (2022) Ind. Crops Prod, 186, p. 115231; Zhang, Q.-W., Lin, L.-G., Ye, W.-C., Techniques for extraction and isolation of natural products: A comprehensive review (2018) Chin. Med, 13, p. 20; Mena-García, A., Ruiz-Matute, A.I., Soria, A.C., Sanz, M.L., Green techniques for extraction of bioactive carbohydrates (2019) TrAC Trends Anal. Chem, 119, p. 115612; Selvamuthukumaran, M., Shi, J., Recent advances in extraction of antioxidants from plant by-products processing industries (2017) Food Qual. Saf, 1, pp. 61-81; Jäger, S., Beffert, M., Hoppe, K., Nadberezny, D., Frank, B., Scheffler, A., Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example (2011) Sci. Pharm, 79, pp. 145-155; Ali, A., Chua, B.L., Chow, Y.H., An insight into the extraction and fractionation technologies of the essential oils and bioactive compounds in Rosmarinus officinalis L.: Past, present and future (2019) TrAC Trends Anal. Chem, 118, pp. 338-351; Chin, F.S., Chong, K.P., Markus, A., Wong, N.K., Tea polyphenols and alkaloids content using Soxhlet and direct extraction method (2013) World J. Agric. Sci, 9, pp. 266-270; Kumar, K., Srivastav, S., Sharanagat, V.S., Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review (2021) Ultrason. Sonochem, 70, p. 105325. , 32920300; Mandal, V., Mohan, Y., Hemalatha, S., Microwave Assisted Extraction-An Innovative and Promising Extraction Tool for Medicinal Plant Research (2007) Pharmacogn. Rev, 1, pp. 7-18; Zwingelstein, M., Draye, M., Besombes, J.-L., Piot, C., Chatel, G., Viticultural wood waste as a source of polyphenols of interest: Opportunities and perspectives through conventional and emerging extraction methods (2020) Waste Manag, 102, pp. 782-794; Hämäläinen, H., Ruusunen, M., Identification of a Supercritical Fluid Extraction Process for Modelling the Energy Consumption (2021) SSRN J, 252, p. 124033; Ahmad, T., Masoodi, F.A., Rather, S.A., Wani, S.M., Gull, A.J., Supercritical Fluid Extraction: A Review (2019) J. Biol. Chem. Chron, 5, pp. 114-122; Patel, D.D., Lee, J.-M., Applications of ionic liquids (2012) Chem. Rec, 12, pp. 329-355; Singh, S.K., Solubility of lignin and chitin in ionic liquids and their biomedical applications (2019) Int. J. Biol. Macromol, 132, pp. 265-277; Choi, Y.H., Verpoorte, R., Green solvents for the extraction of bioactive compounds from natural products using ionic liquids and deep eutectic solvents (2019) Curr. Opin. Food Sci, 26, pp. 87-93; Yang, Z., Natural Deep Eutectic Solvents and Their Applications in Biotechnology (2019) Adv. Biochem. Eng. Biotechnol, 168, pp. 31-59; Liu, Y., Friesen, J.B., McAlpine, J.B., Lankin, D.C., Chen, S.-N., Pauli, G.F., Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives (2018) J. Nat. Prod, 81, pp. 679-690; Marathe, S.J., Jadhav, S.B., Bankar, S.B., Singhal, R.S., Enzyme-Assisted Extraction of Bioactives (2017) Food Bioactives, pp. 171-201. , Springer, Berlin/Heidelberg, Germany; Xia, Y., Wang, Y., Li, W., Ma, C., Liu, S., Homogenization-assisted cavitation hybrid rotation extraction and macroporous resin enrichment of dihydroquercetin from Larix gmelinii (2017) J. Chromatogr. B, 1070, pp. 62-69; Gligor, O., Mocan, A., Moldovan, C., Locatelli, M., Crișan, G., Ferreira, I.C., Enzyme-assisted extractions of polyphenols—A comprehensive review (2019) Trends Food Sci. Technol, 88, pp. 302-315; Wang, L., Weller, C.L., Recent advances in extraction of nutraceuticals from plants (2006) Trends Food Sci. Technol, 17, pp. 300-312; Chupin, L., Maunu, S.L., Reynaud, S., Pizzi, A., Charrier, B., Charrier-EL Bouhtoury, F., Microwave assisted extraction of maritime pine (Pinus pinaster) bark: Impact of particle size and characterization (2015) Ind. Crops Prod, 65, pp. 142-149; Jovanović, A.A., Đorđević, V.B., Zdunić, G.M., Pljevljakušić, D.S., Šavikin, K.P., Gođevac, D.M., Bugarski, B.M., Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques (2017) Sep. Purif. Technol, 179, pp. 369-380; Li, H., Deng, Z., Wu, T., Liu, R., Loewen, S., Tsao, R., Microwave-assisted extraction of phenolics with maximal antioxidant activities in tomatoes (2012) Food Chem, 130, pp. 928-936; Aspé, E., Fernández, K., The effect of different extraction techniques on extraction yield, total phenolic, and anti-radical capacity of extracts from Pinus radiata Bark (2011) Ind. Crops Prod, 34, pp. 838-844; Schreck, R., Baeuerle, P.A., A role for oxygen radicals as second messengers (1991) Trends Cell Biol, 1, pp. 39-42; Wang, H., Kochevar, I.E., Involvement of UVB-induced reactive oxygen species in TGF-beta biosynthesis and activation in keratinocytes (2005) Free. Radic. Biol. Med, 38, pp. 890-897. , 15749385; Maya-Cano, D.A., Arango-Varela, S., Santa-Gonzalez, G.A., Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity (2021) Heliyon, 7; Naidoo, K., Birch-Machin, M., Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) Cosmetics, 4; Trüeb, R.M., Oxidative stress and its impact on skin, scalp and hair (2021) Int. J. Cosmet. Sci, 43, pp. S9-S13. , 34424547; Halliwell, B., Gutteridge, J.M.C., (2015) Free Radicals in Biology and Medicine, , Oxford University Press, Oxford, UK; Young, I.S., Woodside, J.V., Antioxidants in health and disease (2001) J. Clin. Pathol, 54, pp. 176-186. , 11253127; Mirończuk-Chodakowska, I., Witkowska, A.M., Zujko, M.E., Endogenous non-enzymatic antioxidants in the human body (2018) Adv. Med. Sci, 63, pp. 68-78; Ahmad, P., Jaleel, C.A., Salem, M.A., Nabi, G., Sharma, S., Roles of enzymatic and nonenzymatic antioxidants in plants during abiotic stress (2010) Crit. Rev. Biotechnol, 30, pp. 161-175; Sulaiman, M., An Overview of Natural Plant Antioxidants: Analysis and Evaluation (2013) Adv. Biochem, 1, p. 64; Gascón, S., Jiménez-Moreno, N., Jiménez, S., Quero, J., Rodríguez-Yoldi, M.J., Ancín-Azpilicueta, C., Nutraceutical composition of three pine bark extracts and their antiproliferative effect on Caco-2 cells (2018) J. Funct. Foods, 48, pp. 420-429; Skrypnik, L., Grigorev, N., Michailov, D., Antipina, M., Danilova, M., Pungin, A., Comparative study on radical scavenging activity and phenolic compounds content in water bark extracts of alder (Alnus glutinosa (L.) Gaertn.), oak (Quercus robur L.) and pine (Pinus sylvestris L.) (2019) Eur. J. Wood Prod, 77, pp. 879-890; Agarwal, C., Hofmann, T., Visi-Rajczi, E., Pásztory, Z., Low-frequency, green sonoextraction of antioxidants from tree barks of Hungarian woodlands for potential food applications (2021) Chem. Eng. Process. Process Intensif, 159, p. 108221; Emrich, S., Schuster, A., Schnabel, T., Oostingh, G.J., Antimicrobial Activity and Wound-Healing Capacity of Birch, Beech and Larch Bark Extracts (2022) Molecules, 27; Hofmann, T., Nebehaj, E., Stefanovits-Bányai, É., Albert, L., Antioxidant capacity and total phenol content of beech (Fagus sylvatica L.) bark extracts (2015) Ind. Crops Prod, 77, pp. 375-381; Sillero, L., Prado, R., Labidi, J., Optimization of different extraction methods to obtaining bioactive compounds from larix decidua bark (2018) Chem. Eng. Trans, 70, pp. 1369-1374; Sillero, L., Prado, R., Labidi, J., Simultaneous microwave-ultrasound assisted extraction of bioactive compounds from bark (2020) Chem. Eng. Process. Process Intensif, 156, p. 108100; Singh, G., Passsari, A.K., Leo, V.V., Mishra, V.K., Subbarayan, S., Singh, B.P., Kumar, B., Lalhlenmawia, H., Evaluation of Phenolic Content Variability along with Antioxidant, Antimicrobial, and Cytotoxic Potential of Selected Traditional Medicinal Plants from India (2016) Front. Plant Sci, 7, p. 407. , 27066046; Dudonné, S., Vitrac, X., Coutière, P., Woillez, M., Mérillon, J.-M., Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays (2009) J. Agric. Food Chem, 57, pp. 1768-1774. , 19199445; Niroula, A., Khatri, S., Khadka, D., Timilsina, R., Total phenolic contents and antioxidant activity profile of selected cereal sprouts and grasses (2019) Int. J. Food Prop, 22, pp. 427-437; Piluzza, G., Bullitta, S., Correlations between phenolic content and antioxidant properties in twenty-four plant species of traditional ethnoveterinary use in the Mediterranean area (2011) Pharm. Biol, 49, pp. 240-247; Kumar, S., Krishna Chaitanya, R., Preedy, V.R., Assessment of Antioxidant Potential of Dietary Components (2018) HIV/AIDS, pp. 239-253. , Academic Press, Cambridge, MA, USA, Chapter 20; Dalle-Donne, I., Rossi, R., Giustarini, D., Milzani, A., Colombo, R., Protein carbonyl groups as biomarkers of oxidative stress (2003) Clin. Chim. Acta Int. J. Clin. Chem, 329, pp. 23-38; Wehr, N.B., Levine, R.L., (2013) Quantification of Protein Carbonylation. Cell Senescence, pp. 265-281. , Humana Press, Totowa, NJ, USA; Zitka, O., Skalickova, S., Gumulec, J., Masarik, M., Adam, V., Hubalek, J., Trnkova, L., Kizek, R., Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients (2012) Oncol. Lett, 4, pp. 1247-1253; Jaganjac, M., Sredoja Tisma, V., Zarkovic, N., Short Overview of Some Assays for the Measurement of Antioxidant Activity of Natural Products and Their Relevance in Dermatology (2021) Molecules, 26; Agarwal, C., Hofmann, T., Vršanská, M., Schlosserová, N., Visi-Rajczi, E., Voběrková, S., Pásztory, Z., In vitro antioxidant and antibacterial activities with polyphenolic profiling of wild cherry, the European larch and sweet chestnut tree bark (2021) Eur. Food Res. Technol, 247, pp. 2355-2370; Polka, D., Podsędek, A., Koziołkiewicz, M., Comparison of Chemical Composition and Antioxidant Capacity of Fruit, Flower and Bark of Viburnum opulus (2019) Plant Foods Hum. Nutr, 74, pp. 436-442; Siddhuraju, P., Studies on the antioxidant activity of Indian Laburnum (Cassia fistula L.): A preliminary assessment of crude extracts from stem bark, leaves, flowers and fruit pulp (2002) Food Chem, 79, pp. 61-67; Khan, M.A., Rahman, A.A., Islam, S., Khandokhar, P., Parvin, S., Islam, M.B., Hossain, M., Nasrin, S., A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae) (2013) BMC Res. Notes, 6. , 23331970; Dróżdż, P., Pyrzynska, K., Assessment of polyphenol content and antioxidant activity of oak bark extracts (2018) Eur. J. Wood Prod, 76, pp. 793-795; García-Pérez, M.-E., Royer, M., Duque-Fernandez, A., Diouf, P.N., Stevanovic, T., Pouliot, R., Antioxidant, toxicological and antiproliferative properties of Canadian polyphenolic extracts on normal and psoriatic keratinocytes (2010) J. Ethnopharmacol, 132, pp. 251-258; Touriño, S., Selga, A., Jiménez, A., Juliá, L., Lozano, C., Lizárraga, D., Cascante, M., Torres, J.L., Procyanidin fractions from pine (Pinus pinaster) bark: Radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells (2005) J. Agric. Food Chem, 53, pp. 4728-4735. , 15941307; Lee, K.W., Kim, Y.J., Kim, D.-O., Lee, H.J., Lee, C.Y., Major phenolics in apple and their contribution to the total antioxidant capacity (2003) J. Agric. Food Chem, 51, pp. 6516-6520. , 14558772; Sutcliffe, T.C., Winter, A.N., Punessen, N.C., Linseman, D.A., Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress (2017) Antioxidants, 6. , 29027929; Rodríguez-Ramiro, I., Ramos, S., Bravo, L., Goya, L., Martín, M.Á., Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway (2011) J. Nutr. Biochem, 22, pp. 1186-1194. , 21334869; Marini, A., Grether-Beck, S., Jaenicke, T., Weber, M., Burki, C., Formann, P., Brenden, H., Krutmann, J., Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women (2012) Skin Pharmacol. Physiol, 25, pp. 86-92. , 22270036; Furumura, M., Sato, N., Kusaba, N., Takagaki, K., Nakayama, J., Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin (2012) Clin. Interv. Aging, 7, pp. 275-286; Saliou, C., Rimbach, G., Moini, H., McLaughlin, L., Hosseini, S., Lee, J., Watson, R.R., Packer, L., Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract (2001) Free Radic. Biol. Med, 30, pp. 154-160; Zhao, H., Wu, J., Wang, N., Grether-Beck, S., Krutmann, J., Wei, L., Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study (2021) Skin Pharmacol. Physiol, 34, pp. 135-145; Kimura, Y., Sumiyoshi, M., French maritime pine bark (Pinus maritima Lam.) extract (Flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice (2010) Photochem. Photobiol, 86, pp. 955-963; Brizi, C., Santulli, C., Micucci, M., Budriesi, R., Chiarini, A., Aldinucci, C., Frosini, M., Neuroprotective Effects of Castanea sativa Mill. Bark Extract in Human Neuroblastoma Cells Subjected to Oxidative Stress (2016) J. Cell. Biochem, 117, pp. 510-520; Ishikado, A., Sono, Y., Matsumoto, M., Robida-Stubbs, S., Okuno, A., Goto, M., King, G.L., Makino, T., Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans (2013) Free Radic. Biol. Med, 65, pp. 1506-1515; He, F., Ru, X., Wen, T., NRF2, a Transcription Factor for Stress Response and Beyond (2020) Int. J. Mol. Sci, 21. , 32640524; Tonelli, C., Chio, I.I.C., Tuveson, D.A., Transcriptional Regulation by Nrf2 (2018) Antioxid. Redox Signal, 29, pp. 1727-1745. , 28899199; Xian, D., Guo, M., Xu, J., Yang, Y., Zhao, Y., Zhong, J., Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses (2021) Redox Rep, 26, pp. 134-146. , 34355664; Nachbar, F., Korting, H.C., The role of vitamin E in normal and damaged skin (1995) J. Mol. Med, 73, pp. 7-17; Choubey, V., Sarkar, R., Garg, V., Kaushik, S., Ghunawat, S., Sonthalia, S., Role of oxidative stress in melasma: A prospective study on serum and blood markers of oxidative stress in melasma patients (2017) Int. J. Dermatol, 56, pp. 939-943; Ji, H., Li, X.-K., Oxidative Stress in Atopic Dermatitis (2016) Oxidative Med. Cell. Longev, 2016, p. 2721469; Sarici, G., Cinar, S., Armutcu, F., Altinyazar, C., Koca, R., Tekin, N.S., Oxidative stress in acne vulgaris (2010) J. Eur. Acad. Dermatol. Venereol, 24, pp. 763-767; Kaur, S., Zilmer, K., Leping, V., Zilmer, M., Allergic contact dermatitis is associated with significant oxidative stress (2014) Dermatol. Res. Pract, 2014, p. 415638; Emre, S., Metin, A., Demirseren, D.D., Akoglu, G., Oztekin, A., Neselioglu, S., Erel, O., The association of oxidative stress and disease activity in seborrheic dermatitis (2012) Arch. Dermatol. Res, 304, pp. 683-687; Acharya, P., Mathur, M.C., Oxidative stress in alopecia areata: A systematic review and meta-analysis (2020) Int. J. Dermatol, 59, pp. 434-440; Tisma, V.S., Basta-Juzbasic, A., Jaganjac, M., Brcic, L., Dobric, I., Lipozencic, J., Tatzber, F., Poljak-Blazi, M., Oxidative stress and ferritin expression in the skin of patients with rosacea (2009) J. Am. Acad. Dermatol, 60, pp. 270-276; Yang, L., Xian, D., Xiong, X., Lai, R., Song, J., Zhong, J., Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications (2018) BioMed Res. Int, 2018, p. 8584136. , 29750172; Chaiprasongsuk, A., Panich, U., Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2 (2022) Front. Pharmacol, 13, p. 823881. , 35645796; Klemow, K.M., Bartlow, A., Crawford, J., Kocher, N., Shah, J., Ritsick, M., (2011) Herbal Medicine: Biomolecular and Clinical Aspects, , Shenefelt P.D., (ed), 2nd ed., CRC Press/Taylor & Francis, Abingdon, UK; Park, C., Park, J., Kim, W.-J., Kim, W., Cheong, H., Kim, S.-J., Malonic Acid Isolated from Pinus densiflora Inhibits UVB-Induced Oxidative Stress and Inflammation in HaCaT Keratinocytes (2021) Polymers, 13; Parzonko, A., Kiss, A.K., Caffeic acid derivatives isolated from Galinsoga parviflora herb protected human dermal fibroblasts from UVA-radiation (2019) Phytomedicine, 57, pp. 215-222; Ni, Z., Mu, Y., Gulati, O., Treatment of melasma with Pycnogenol (2002) Phytother. Res, 16, pp. 567-571; García-Pérez, M.-E., Allaeys, I., Rusu, D., Pouliot, R., Janezic, T.S., Poubelle, P.E., Picea mariana polyphenolic extract inhibits phlogogenic mediators produced by TNF-α-activated psoriatic keratinocytes: Impact on NF-κB pathway (2014) J. Ethnopharmacol, 151, pp. 265-278; Smiljanic, S., Messaraa, C., Lafon-Kolb, V., Hrapovic, N., Amini, N., Osterlund, C., Visdal-Johnsen, L., Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits (2022) Int. J. Mol. Sci, 23. , 36293365; Terreni, M., Taccani, M., Pregnolato, M., New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives (2021) Molecules, 26. , 34063264; Pan, S.-Y., Litscher, G., Gao, S.-H., Zhou, S.-F., Yu, Z.-L., Chen, H.-Q., Zhang, S.-F., Ko, K.-M., Historical perspective of traditional indigenous medical practices: The current renaissance and conservation of herbal resources (2014) Evid.-Based Complement. Altern. Med, 2014, p. 525340; Barbieri, R., Coppo, E., Marchese, A., Daglia, M., Sobarzo-Sánchez, E., Nabavi, S.F., Nabavi, S.M., Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity (2017) Microbiol. Res, 196, pp. 44-68; Miklasińska-Majdanik, M., Kępa, M., Wojtyczka, R.D., Idzik, D., Wąsik, T.J., Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains (2018) Int. J. Environ. Res. Public Health, 15; Park, K.D., Cho, S.J., Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: Improvement of stability and proposed action mechanism (2010) Eur. J. Med. Chem, 45, pp. 1028-1033; Kang, S.S., Kim, J.-G., Lee, T.-H., Oh, K.-B., Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen (2006) Biol. Pharm. Bull, 29, pp. 1751-1755; Lin, R.-D., Chin, Y.-P., Hou, W.-C., Lee, M.-H., The effects of antibiotics combined with natural polyphenols against clinical methicillin-resistant Staphylococcus aureus (MRSA) (2008) Planta Med, 74, pp. 840-846; Zhao, W.-H., Hu, Z.-Q., Hara, Y., Shimamura, T., Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus (2002) Antimicrob. Agents Chemother, 46, pp. 2266-2268; Qin, R., Xiao, K., Li, B., Jiang, W., Peng, W., Zheng, J., Zhou, H., The combination of catechin and epicatechin callate from Fructus Crataegi potentiates beta-lactam antibiotics against methicillin-resistant staphylococcus aureus (MRSA) in vitro and in vivo (2013) Int. J. Mol. Sci, 14, pp. 1802-1821; Balouiri, M., Sadiki, M., Ibnsouda, S.K., Methods for in vitro evaluating antimicrobial activity: A review (2016) J. Pharm. Anal, 6, pp. 71-79; Valgas, C., de Souza, S.M., Smânia, E.F.A., Smânia, A., Jr., Screening methods to determine antibacterial activity of natural products (2007) Braz. J. Microbiol, 38, pp. 369-380; Morales, D., Oak trees (Quercus spp.) as a source of extracts with biological activities: A narrative review (2021) Trends Food Sci. Technol, 109, pp. 116-125; Tanase, C., Nicolescu, A., Nisca, A., Ștefănescu, R., Babotă, M., Mare, A.D., Ciurea, C.N., Man, A., Biological Activity of Bark Extracts from Northern Red Oak (Quercus rubra L.): An Antioxidant, Antimicrobial and Enzymatic Inhibitory Evaluation (2022) Plants, 11; Andrensek, S., Simonovska, B., Vovk, I., Fyhrquist, P., Vuorela, H., Vuorela, P., Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom (2004) Int. J. Food Microbiol, 92, pp. 181-187; Neiva, D.M., Luís, Â., Gominho, J., Domingues, F., Duarte, A.P., Pereira, H., Bark residues valorization potential regarding antioxidant and antimicrobial extracts (2020) Wood Sci. Technol, 54, pp. 559-585; Ferrentino, G., Haman, N., Morozova, K., Tonon, G., Scampicchio, M., Phenolic compounds extracted from spruce (Picea abies) by supercritical carbon dioxide as antimicrobial agents against gram-positive bacteria assessed by isothermal calorimetry (2021) J. Anal. Calorim, 145, pp. 3093-3103; Živković, J., Zeković, Z., Mujić, I., Vidović, S., Cvetković, D., Lepojević, Ž., Nikolić, G., Trutić, N., Scavenging capacity of superoxide radical and screening of antimicrobial activity of Castanea sativa Mill. extracts (2010) Czech J. Food Sci, 28, pp. 61-68; Tanase, C., Cosarca, S., Toma, F., Mare, A., Man, A., Miklos, A., Imre, S., Boz, I., Antibacterial activities of beech bark (Fagus sylvatica L.) polyphenolic extract (2018) Environ. Eng. Manag. J, 17, pp. 877-884; Laireiter, C.M., Schnabel, T., Köck, A., Stalzer, P., Petutschnigg, A., Oostingh, G.J., Hell, M., Active Anti-Microbial Effects of Larch and Pine Wood on Four Bacterial Strains (2013) BioResources, 9, pp. 273-281; Duric, K., Kovac-Besovic, E., Niksic, H., Sofic, E., Antibacterial Activity of Methanolic Extracts, Decoction and Isolated Triterpene Products from Different Parts of Birch, Betula pendula, Roth (2013) J. Plant Stud, 2, p. 61; Torras, M.A.C., Faura, C.A., Schönlau, F., Rohdewald, P., Antimicrobial activity of Pycnogenol (2005) Phytother. Res, 19, pp. 647-648; Keita, K., Darkoh, C., Okafor, F., Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens (2022) SN Appl. Sci, 4, p. 209; Byrd, A.L., Belkaid, Y., Segre, J.A., The human skin microbiome (2018) Nat. Rev. Microbiol, 16, pp. 143-155. , 29332945; Nasri, H., Bahmani, M., Shahinfard, N., Moradi Nafchi, A., Saberianpour, S., Rafieian Kopaei, M., Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences (2015) Jundishapur J. Microbiol, 8, p. e25580; Mayslich, C., Grange, P.A., Dupin, N., Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors (2021) Microorganisms, 9. , 33540667; Dreno, B., Thiboutot, D., Gollnick, H., Bettoli, V., Kang, S., Leyden, J.J., Shalita, A., Torres, V., Antibiotic stewardship in dermatology: Limiting antibiotic use in acne (2014) Eur. J. Dermatol, 24, pp. 330-334; Ayaz, M., Ullah, F., Sadiq, A., Ullah, F., Ovais, M., Ahmed, J., Devkota, H.P., Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance (2019) Chem. Biol. Interact, 308, pp. 294-303. , 31158333; Suntar, I., Sarker, S.D., Nahar, L., Basar, N., Traditional Medicine for Wound Management (2017) Evid.-Based Complement. Altern. Med, 2017, p. 4214382; Wilkinson, H.N., Hardman, M.J., Wound healing: Cellular mechanisms and pathological outcomes (2020) Open Biol, 10, p. 200223; Carvalho, M.T.B., Araújo-Filho, H.G., Barreto, A.S., Quintans-Júnior, L.J., Quintans, J.S.S., Barreto, R.S.S., Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action (2021) Phytomedicine, 90, p. 153636; Vitale, S., Colanero, S., Placidi, M., Di Emidio, G., Tatone, C., Amicarelli, F., D’Alessandro, A.M., Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research (2022) Molecules, 27; Mosae Selvakumar, P., Plant-Derived Compounds for Wound Healing—A Review (2018) Org. Med. Chem. Int. J, 5, pp. 13-17; Maleki, S.J., Crespo, J.F., Cabanillas, B., Anti-inflammatory effects of flavonoids (2019) Food Chem, 299, p. 125124; Singh, W.R., Devi, H.S., Kumawat, S., Sadam, A., Appukuttan, A.V., Patel, M.R., Lingaraju, M.C., Kumar, D., Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats (2019) Eur. J. Pharmacol, 858, p. 172466. , 31220437; Lazaro, J.L., Izzo, V., Meaume, S., Davies, A.H., Lobmann, R., Uccioli, L., Elevated levels of matrix metalloproteinases and chronic wound healing: An updated review of clinical evidence (2016) J. Wound Care, 25, pp. 277-287; https://www.ema.europa.eu/en/medicines/human/EPAR/episalvan#overview-section, Available online; Scheffler, A., The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside (2019) Planta Med, 85, pp. 524-527. , 30856673; Haque, S., Nawrot, D.A., Alakurtti, S., Ghemtio, L., Yli-Kauhaluoma, J., Tammela, P., Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives (2014) PLoS ONE, 9. , 25032708; Schwieger-Briel, A., Ott, H., Kiritsi, D., Laszczyk-Lauer, M., Bodemer, C., Mechanism of Oleogel-S10: A triterpene preparation for the treatment of epidermolysis bullosa (2019) Dermatol. Ther, 32, p. e12983. , 31168940; Kindler, S., Schuster, M., Seebauer, C., Rutkowski, R., Hauschild, A., Podmelle, F., Metelmann, C., Metelmann, H.-R., Triterpenes for Well-Balanced Scar Formation in Superficial Wounds (2016) Molecules, 21. , 27618886; Dehelean, C.A., Soica, C., Ledeţi, I., Aluaş, M., Zupko, I., Gǎluşcan, A., Cinta-Pinzaru, S., Munteanu, M., Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation (2012) Chem. Cent. J, 6, p. 137; Huyke, C., Laszczyk, M., Scheffler, A., Ernst, R., Schempp, C.M., Behandlung aktinischer Keratosen mit Birkenkorkextrakt: Eine Pilotstudie (2006) J. Dtsch. Dermatol. Ges, 4, pp. 132-136; Hemida, H., Doukani, K., Zitouni, A., Miloud, B., Beggar, H., Bouhenni, H., Assessment of wound healing activity of ethanolic extracts of Pistacia lentiscus L. leaves and Quercus ilex L. bark in full thickness skin excision in rats (2022) Adv. Tradit. Med, 22, pp. 589-597; Secim-Karakaya, P., Saglam-Metiner, P., Yesil-Celiktas, O., Antimicrobial and wound healing properties of cotton fabrics functionalized with oil-in-water emulsions containing Pinus brutia bark extract and Pycnogenol® for biomedical applications (2021) Cytotechnology, 73, pp. 423-431; Yesİl-Celİktas, O., A comparative study of antioxidant properties of extracts obtained from renewable forestry and agricultural resources (2009) Fresenius Environ. Bull, 18, pp. 1507-1512; Iravani, S., Zolfaghari, B., Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract (2011) Res. Pharm. Sci, 6, pp. 1-11; Weyns, A.-S., Verlaet, A.A., van Herreweghe, M., Breynaert, A., Fransen, E., de Meester, I., Logie, E., van West, D., Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 2: Oxidative Stress and Immunological Modulation (2022) J. Funct. Foods, 97, p. 105247; Cretu, E., Karonen, M., Salminen, J.-P., Mircea, C., Trifan, A., Charalambous, C., Constantinou, A.I., Miron, A., In vitro study on the antioxidant activity of a polyphenol-rich extract from Pinus brutia bark and its fractions (2013) J. Med. Food, 16, pp. 984-991; Angelis, A., Hubert, J., Aligiannis, N., Michalea, R., Abedini, A., Nuzillard, J.-M., Gangloff, S.C., Renault, J.-H., Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties (2016) Molecules, 21; Coșarcă, S.-L., Moacă, E.-A., Tanase, C., Muntean, D.L., Pavel, I.Z., Dehelean, C.A., Spruce and beech bark aqueous extracts: Source of polyphenols, tannins and antioxidants correlated to in vitro antitumor potential on two different cell lines (2019) Wood Sci. Technol, 53, pp. 313-333; Tanase, C., Mocan, A., Coșarcă, S., Gavan, A., Nicolescu, A., Gheldiu, A.-M., Vodnar, D.C., Crișan, O., Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties (2019) Antioxidants, 8; Abyshev, A.Z., Agaev, É.M., Guseinov, A.B., Studies of the chemical composition of birch bark extracts (Cortex betula) from the Betulaceae family (2007) Pharm. Chem. J, 41, pp. 419-423; Preda, M., Cheveresan, A., Pinzaru, I., Dobrescu, A., Pavel, I.Z., Vlaia, V., Sisu, E., Chemical Composition and Biological Activity of Birch Bark Extracts on Human and Murine Healthy/Melanoma Cell Lines (2018) Rev. Chim, 69, pp. 1907-1910; Bito, T., Roy, S., Sen, C.K., Packer, L., Pine bark extract pycnogenol downregulates IFN-γ-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression (2000) Free Radic. Biol. Med, 28, pp. 219-227. , 11281289; Smailagić, A., Ristivojević, P., Dimkić, I., Pavlović, T., Dabić Zagorac, D., Veljović, S., Fotirić Akšić, M., Natić, M., Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts (2020) Foods, 9. , 32164204; Sulaiman, G.M., Hussien, N.N., Marzoog, T.R., Awad, H.A., Phenolic content, antioxidant, antimicrobial and cytotoxic activities of ethanolic extract of salix alba (2013) Am. J. Biochem. Biotechnol, 9, pp. 41-46; Tienaho, J., Reshamwala, D., Sarjala, T., Kilpeläinen, P., Liimatainen, J., Dou, J., Viherä-Aarnio, A., Jyske, T., Salix spp. Bark Hot Water Extracts Show Antiviral, Antibacterial, and Antioxidant Activities-The Bioactive Properties of 16 Clones (2021) Front. Bioeng. Biotechnol, 9, p. 797939. , 34976988

PY - 2023/1/9

Y1 - 2023/1/9

N2 - Plant species have developed effective defense strategies for colonizing diverse habitats and protecting themselves from numerous attacks from a wide range of organisms, including insects, vertebrates, fungi, and bacteria. The bark of trees in particular constitutes a number of components that protect against unwanted intruders. This review focuses on the antioxidative, dermal immunomodulatory, and antimicrobial properties of bark extracts from European common temperate trees in light of various skin pathogens, wound healing, and the maintenance of skin health. The sustainability aspect, achieved by utilizing the bark, which is considered a byproduct in the forest industry, is addressed, as are various extraction methods applied to retrieve extracts from bark.

AB - Plant species have developed effective defense strategies for colonizing diverse habitats and protecting themselves from numerous attacks from a wide range of organisms, including insects, vertebrates, fungi, and bacteria. The bark of trees in particular constitutes a number of components that protect against unwanted intruders. This review focuses on the antioxidative, dermal immunomodulatory, and antimicrobial properties of bark extracts from European common temperate trees in light of various skin pathogens, wound healing, and the maintenance of skin health. The sustainability aspect, achieved by utilizing the bark, which is considered a byproduct in the forest industry, is addressed, as are various extraction methods applied to retrieve extracts from bark.

KW - antimicrobial potential

KW - antioxidative potential

KW - dermatology

KW - European wood bark extracts

KW - extraction technologies

KW - Abies alba extract

KW - Acer pseudoplatanus extract

KW - Alnus glutinosa extract

KW - Betula pendula extract

KW - Castanea sativa extract

KW - Fagus sylvatica extract

KW - Fraxinus excelsior extract

KW - glutathione

KW - immunoglobulin enhancer binding protein

KW - Larix decidua extract

KW - malonaldehyde

KW - Picea abies extract

KW - Pinus brutia extract

KW - Pinus pinaster extract

KW - plant extract

KW - Prunus avium extract

KW - Prunus padus extract

KW - Pseudotsuga menziesii extract

KW - Quercus ilex extract

KW - Quercus robur extract

KW - Quercus rubra extract

KW - reactive oxygen metabolite

KW - Salix alba extract

KW - superoxide dismutase

KW - thiobarbituric acid

KW - thiobarbituric acid reactive substance

KW - transcription factor Nrf2

KW - tumor necrosis factor

KW - unclassified drug

KW - ABTS radical scavenging assay

KW - antibacterial activity

KW - antimicrobial activity

KW - antioxidant activity

KW - bark

KW - DNA damage

KW - DPPH radical scavenging assay

KW - extraction

KW - ferric reducing antioxidant power assay

KW - human

KW - hydrodistillation

KW - immune response

KW - immunomodulation

KW - lipid peroxidation

KW - maceration

KW - MAPK signaling

KW - microwave assisted extraction

KW - NF kB signaling

KW - nonhuman

KW - oxidative stress

KW - Pi3K/Akt signaling

KW - Review

KW - Soxhlet extraction

KW - steam distillation

KW - synergistic effect

KW - wound healing

KW - wound healing assay

UR - https://www.mendeley.com/catalogue/294c0317-1d49-394f-9693-95f159a2634d/

U2 - 10.3390/antibiotics12010130

DO - 10.3390/antibiotics12010130

M3 - Review article

C2 - 36671331

SN - 2079-6382

VL - 12

SP - 130

JO - Antibiotics

JF - Antibiotics

IS - 1

ER -

Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications

Abstract

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Die Nutzung der Wertstoffe aus forstliche Biomasse nach den Gesichtspunkten der Kreislaufwirtschaft und Bioökonomie

Research Results from Salzburg University of Applied Sciences Update Understanding of Antibiotics (Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications)

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Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications

Abstract

UN SDGs

Keywords

Classification according to Österreichische Systematik der Wissenschaftszweige (ÖFOS 2012)

Applied Research Level (ARL)

Research focus/foci

Access to Document

Other files and links

Fingerprint

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Die Nutzung der Wertstoffe aus forstliche Biomasse nach den Gesichtspunkten der Kreislaufwirtschaft und Bioökonomie

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Research Results from Salzburg University of Applied Sciences Update Understanding of Antibiotics (Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications)

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